| Gene Symbol |
KLHL25
|
| Entrez Gene |
64410
|
| Alt Symbol |
ENC-2, ENC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kelch-like family member 25
|
| Other Description |
BTB/POZ KELCH domain protein|ectoderm-neural cortex protein 2|ectodermal-neural cortex 2|kelch-like 25|kelch-like protein 25
|
| Swissprots |
B3KRT7 B2RDH2 Q9H0H3
|
| Accessions |
EAX01979 Q9H0H3 AK022649 BAB14155 AK056663 BAG51779 AK092231 BAG52499 AK126962 AK315541 BAG37919 AL109693 AL136796 CAB66730 AM393017 CAL37895 AM393776 CAL38651 AY764034 AAV51405 BC028100 AAH28100 DA337553 DB063745 EU446519 ABZ92048 NM_022480 NP_071925
|
| Function |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. {ECO:0000269|PubMed:22578813}.
|