KLHL25

Gene Symbol	KLHL25
Entrez Gene	64410
Alt Symbol	ENC-2, ENC2
Species	Human
Gene Type	protein-coding
Description	kelch-like family member 25
Other Description	BTB/POZ KELCH domain protein|ectoderm-neural cortex protein 2|ectodermal-neural cortex 2|kelch-like 25|kelch-like protein 25
Swissprots	B3KRT7 B2RDH2 Q9H0H3
Accessions	EAX01979 Q9H0H3 AK022649 BAB14155 AK056663 BAG51779 AK092231 BAG52499 AK126962 AK315541 BAG37919 AL109693 AL136796 CAB66730 AM393017 CAL37895 AM393776 CAL38651 AY764034 AAV51405 BC028100 AAH28100 DA337553 DB063745 EU446519 ABZ92048 NM_022480 NP_071925
Function	Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. {ECO:0000269|PubMed:22578813}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KLHL25 overexpression lysate - LY411647 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

KLHL25 293 Cell Lysate - 405821 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Drosophila

KLHL25 Overexpression Lysate (Native) - NBL1-12338 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

KLHL25 Over-expression Lysate Product - GWB-B05350 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human KLHL25 Knockdown Stable Cell Line - CSC-DC008283 from Creative biogene Category Cell Line Species Human

Search more