IL1R2

Gene Symbol	IL1R2
Entrez Gene	7850
Alt Symbol	CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor, type II
Other Description	CD121 antigen-like family member B|IL-1 type II receptor|IL-1R-beta|antigen CDw121b|interleukin 1 receptor type II variant 3|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II|type II interleukin-1 receptor, beta
Swissprots	Q9UE68 P27930 D3DVJ5 Q6LCE6
Accessions	AAK52072 AAM64221 CAD19056 CAD28169 CAD57172 CAI84626 CAL63915 CBX46851 EAX01800 EAX01801 EAX01802 EAX01803 P27930 AK130412 AK309161 BC012346 BC027733 AAH27733 BC039031 AAH39031 DC380050 FJ200480 ACO54877 HQ448529 ADQ33008 U64094 AAB05878 U74649 AAD00242 X59770 CAA42441 XM_006712734 XP_006712797 XM_006712736 XP_006712799 XM_011511801 XP_011510103 XM_011511802 XP_011510104 XM_011511803 XP_011510105 XM_011511804 XP_011510106 XM_011511805 XP_011510107 XM_011511806 XP_011510108 XM_011511807 XP_011510109 XM_011511808 XP_011510110 XR_923024 NM_001261419 NP_001248348 NM_004633 NP_004624 NR_048564 NM_173343
Function	Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.
Subcellular Location	Isoform Short: Secreted {ECO:0000269|PubMed:8702856}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CD121b / IL1R2 ELISA Kit (Sandwich ELISA) - LS-F2465 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 32-2000 pg/ml

Human CD121b / IL1R2 ELISA Kit (Sandwich ELISA) - LS-F5096 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 32-2000 pg/ml

Mouse CD121b / IL1R2 ELISA Kit (Sandwich ELISA) - LS-F5541 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 32-2000 pg/ml

Rhesus monkey CD121b / IL1R2 ELISA Kit (Sandwich ELISA) - LS-F6102 from LifeSpan Bioscience Category ELISA Kit Prices $830.00 Sizes 1 plate Sensitivity 0.213 ng/ml Range 32-2000 pg/ml

Human CD121b / IL1R2 ELISA Kit (Sandwich ELISA) - LS-F992 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 32-2000 pg/ml

Human IL-1 sRII ELISA Kit - RAB0280 from Sigma-Aldrich Category ELISA Kit Prices $666.00 Sizes 1 kt

Human IL-1 RII Quantikine ELISA Kit - DR1B00 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 10 pg/mL Range 31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)

Human IL-1 RII DuoSet ELISA - DY263 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

IL-1 R2 ELISA Kit (Human) : 96 Wells (OKAG00129) - OKAG00129 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 32 pg/mL Range 32-2,000 pg/mL

Human IL1R2 ELISA Kit - abx151934 from Abbexa Category ELISA Kit Sensitivity 6.1 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Interleukin 1 Receptor Type II, IL-1R2, Human, ELISA Kit - E-EL-H0090 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Interleukin 1 Receptor Type II (IL1R2), Human, ELISA Kit - SEA065Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 6.1pg/mL Range 15.6-1,000pg/mL

Interleukin-1 receptor type 2, IL1R2, Human, ELISA Kit - E0066h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 31.2-2000 pg/mL

Soluble interleukin-1 receptor I, IL-1sRI, Human, ELISA Kit - CSB-E04612h from ARP American Research Products Category ELISA Kit Prices $450.00, $595.00, $596.00, $599.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

IL1R2 (Human) ELISA Kit - KA2211 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human IL-1 sRII ELISA - ELH-IL1R2 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 5 pg/ml Range 5 pg/ml - 3000 pg/ml

Interleukin 1, ELISA Kit - MBS009489 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.0pg/ml Range 15.6pg/ml-500pg/ml

Interleukin 1, ELISA Kit - MBS092951 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1, ELISA Kit - MBS035863 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1, ELISA Kit - MBS055084 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1, ELISA Kit - MBS064314 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0pg/ml. Range 31.2pg/ml-1000pg/ml.

Interleukin 1, ELISA Kit - MBS032829 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 5.0 pg/ml Range 31.2 pg/ml - 1000 pg/ml

Interleukin 1, ELISA Kit - MBS006229 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1, ELISA Kit - MBS034397 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.0pg/ml. Range 15.6pg/ml-500pg/ml.

Interleukin 1, ELISA Kit - MBS026486 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.0pg/ml. Range 15.6pg/ml-500pg/ml.

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