IL1R2

Gene Symbol	IL1R2
Entrez Gene	7850
Alt Symbol	CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor, type II
Other Description	CD121 antigen-like family member B|IL-1 type II receptor|IL-1R-beta|antigen CDw121b|interleukin 1 receptor type II variant 3|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II|type II interleukin-1 receptor, beta
Swissprots	Q9UE68 P27930 D3DVJ5 Q6LCE6
Accessions	AAK52072 AAM64221 CAD19056 CAD28169 CAD57172 CAI84626 CAL63915 CBX46851 EAX01800 EAX01801 EAX01802 EAX01803 P27930 AK130412 AK309161 BC012346 BC027733 AAH27733 BC039031 AAH39031 DC380050 FJ200480 ACO54877 HQ448529 ADQ33008 U64094 AAB05878 U74649 AAD00242 X59770 CAA42441 XM_006712734 XP_006712797 XM_006712736 XP_006712799 XM_011511801 XP_011510103 XM_011511802 XP_011510104 XM_011511803 XP_011510105 XM_011511804 XP_011510106 XM_011511805 XP_011510107 XM_011511806 XP_011510108 XM_011511807 XP_011510109 XM_011511808 XP_011510110 XR_923024 NM_001261419 NP_001248348 NM_004633 NP_004624 NR_048564 NM_173343
Function	Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.
Subcellular Location	Isoform Short: Secreted {ECO:0000269|PubMed:8702856}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human IL1 Receptor II protein fragment - ab174069 from Abcam Category Protein Prices $372.00 Sizes 100 µg Source HEK 293 cells Species Human

Human IL1 Receptor II protein fragment - ab127158 from Abcam Category Protein Source E. coli Species Human

CD121b / IL1R2 Antibody Blocking Peptide - LS-E698 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CD121b / IL1R2 Antibody Blocking Peptide - LS-E27391 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IL-1 RII Partial Recombinant Protein - H00007850-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human IL-1 RII Protein - H00007850-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

IL1R2-Antibody-Center-Blocking-peptide - BP11048c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IL1 Receptor 2 blocking peptide - GTX88100-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Recombinant Human IL-1 RII - 263-2R-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Phe14-Glu343

Recombinant Human IL-1 RII, CF - 263-2R-050/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Phe14-Glu343

Recombinant Human IL-1 RII Fc Chimera, CF - 663-2R-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived

Recombinant Mouse IL-1 RII Fc Chimera, CF - 563-MR-100 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived

Cynomolgus IL1R2 protein - orb139164 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells

Human IL1R2 protein - orb139165 from Biorbyt Category Protein Prices $434.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Canine IL1R2 protein - orb139166 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 20 μg, 50 μg Source Human Cells

IL1 Receptor II Peptide - AC21-2215-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD121b / IL1R2 - H00007850-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD121b / IL1R2 - H00007850-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD121b / IL1R2 - H00007850-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IL1R2 Peptide - 42-608P from ProSci Category Peptide

IL 1 R2 Recombinant Protein - 96-436 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

IL1 R2 Recombinant Protein - 96-437 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

IL1R2 fusion protein - ag4495 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human IL1R2, His tagged - IL1R2-2200H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human IL1R2, Fc tagged - IL1R2-773H from Creative Biomart Category Protein Source Human Cells Species Human

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