IL1R2
| Gene Symbol | IL1R2 |
|---|---|
| Entrez Gene | 7850 |
| Alt Symbol | CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor, type II |
| Other Description | CD121 antigen-like family member B|IL-1 type II receptor|IL-1R-beta|antigen CDw121b|interleukin 1 receptor type II variant 3|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II|type II interleukin-1 receptor, beta |
| Swissprots | Q9UE68 P27930 D3DVJ5 Q6LCE6 |
| Accessions | AAK52072 AAM64221 CAD19056 CAD28169 CAD57172 CAI84626 CAL63915 CBX46851 EAX01800 EAX01801 EAX01802 EAX01803 P27930 AK130412 AK309161 BC012346 BC027733 AAH27733 BC039031 AAH39031 DC380050 FJ200480 ACO54877 HQ448529 ADQ33008 U64094 AAB05878 U74649 AAD00242 X59770 CAA42441 XM_006712734 XP_006712797 XM_006712736 XP_006712799 XM_011511801 XP_011510103 XM_011511802 XP_011510104 XM_011511803 XP_011510105 XM_011511804 XP_011510106 XM_011511805 XP_011510107 XM_011511806 XP_011510108 XM_011511807 XP_011510109 XM_011511808 XP_011510110 XR_923024 NM_001261419 NP_001248348 NM_004633 NP_004624 NR_048564 NM_173343 |
| Function | Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}. |
| Subcellular Location | Isoform Short: Secreted {ECO:0000269|PubMed:8702856}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection |
IL-1RII CRISPR/Cas9 KO Plasmid (h) - sc-417044 from Santa Cruz Biotechnology
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IL-1RII HDR Plasmid (h) - sc-417044-HDR from Santa Cruz Biotechnology
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IL-1RII Double Nickase Plasmid (h) - sc-417044-NIC from Santa Cruz Biotechnology
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IL-1RII Double Nickase Plasmid (h2) - sc-417044-NIC-2 from Santa Cruz Biotechnology
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IL-1RII CRISPR Activation Plasmid (h) - sc-417044-ACT from Santa Cruz Biotechnology
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IL-1RII CRISPR Activation Plasmid (h2) - sc-417044-ACT-2 from Santa Cruz Biotechnology
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IL-1RII Lentiviral Activation Particles (h) - sc-417044-LAC from Santa Cruz Biotechnology
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IL-1RII Lentiviral Activation Particles (h2) - sc-417044-LAC-2 from Santa Cruz Biotechnology
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IL-1RII siRNA (h) - sc-72042 from Santa Cruz Biotechnology
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IL-1RII shRNA Plasmid (h) - sc-72042-SH from Santa Cruz Biotechnology
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IL-1RII shRNA (h) Lentiviral Particles - sc-72042-V from Santa Cruz Biotechnology
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IL-1 RII RNAi - H00007850-R04 from Novus Biologicals
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IL-1 RII RNAi - H00007850-R03 from Novus Biologicals
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MISSION® esiRNA - EHU129891 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10597 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10597 from Sigma-Aldrich
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IL1R2 siRNA (Human) - CRH5294 from Cohesion Biosciences
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IL1R2 - MBS8233432 from MyBioSource
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shRNA set against Human IL1R2 (NM_004633.3) - SHH318557 from Creative biogene
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shRNA set against Human IL1R2(NM_004633.3) - SHL134634 from Creative biogene
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Human IL1R2 siRNA - orb265796 from Biorbyt
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IL1R2 shRNA Plasmid (Human) - CHH5294 from Cohesion Biosciences
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IL1R2 miRNA 3'UTR clone - MiUTR1H-04898 from Creative biogene
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