IL1R2

Gene Symbol	IL1R2
Entrez Gene	7850
Alt Symbol	CD121b, CDw121b, IL-1R-2, IL-1RT-2, IL-1RT2, IL1R2c, IL1RB
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor, type II
Other Description	CD121 antigen-like family member B|IL-1 type II receptor|IL-1R-beta|antigen CDw121b|interleukin 1 receptor type II variant 3|interleukin-1 receptor beta|interleukin-1 receptor type 2|interleukin-1 receptor type II|type II interleukin-1 receptor, beta
Swissprots	Q9UE68 P27930 D3DVJ5 Q6LCE6
Accessions	AAK52072 AAM64221 CAD19056 CAD28169 CAD57172 CAI84626 CAL63915 CBX46851 EAX01800 EAX01801 EAX01802 EAX01803 P27930 AK130412 AK309161 BC012346 BC027733 AAH27733 BC039031 AAH39031 DC380050 FJ200480 ACO54877 HQ448529 ADQ33008 U64094 AAB05878 U74649 AAD00242 X59770 CAA42441 XM_006712734 XP_006712797 XM_006712736 XP_006712799 XM_011511801 XP_011510103 XM_011511802 XP_011510104 XM_011511803 XP_011510105 XM_011511804 XP_011510106 XM_011511805 XP_011510107 XM_011511806 XP_011510108 XM_011511807 XP_011510109 XM_011511808 XP_011510110 XR_923024 NM_001261419 NP_001248348 NM_004633 NP_004624 NR_048564 NM_173343
Function	Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.
Subcellular Location	Isoform Short: Secreted {ECO:0000269|PubMed:8702856}.
Top Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, MAPK signaling pathway, Amoebiasis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL1R2-Over-expression-Lysate - LY15460a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

IL1R2 293T Cell Transient Overexpression Lysate(Denatured) - H00007850-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

IL1R2 overexpression lysate - LY401469 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL1R2 293 Cell Lysate - 401334 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IL-1 RII Overexpression Lysate (Denatured) - H00007850-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

IL-1 RII Overexpression Lysate (Native) - NBL1-11928 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL-1 RII Overexpression Lysate (Native) - NBL1-11927 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL-1RII (h): 293T Lysate - sc-115519 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

IL1R2 Over-expression Lysate Product - GWB-CD911C from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

IL1R2 Over-expression Lysate Product - GWB-13FCDA from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Cynomolgus IL1R2 / IL1RB HEK293 Cell Lysate (WB positive control) - 90120-C02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Cynomolgus

Human IL1R2 / IL1RB / CD121b HEK293 Cell Lysate (WB positive control) - 10111-HCCHL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R2 / IL1RB / CD121b HEK293 Cell Lysate (WB positive control) - 10111-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R2 / CD121b HEK293 Cell Lysate (WB positive control) - 10111-H02HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R2 Human Cells Transfected Lysate (positive control) (denatured) - orb174561 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

IL-1 RII Overexpression Lysate (Denatured) - H00007850-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Human IL1R2 Human Cells Transfected Lysate (positive control) (denatured) - orb172941 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Human IL1R2 Human Cells Transfected Lysate (positive control) (denatured) - orb173352 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human IL1R2 Knockdown Stable Cell Line - CSC-DC007563 from Creative biogene Category Cell Line Species Human

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