ICOS

Gene Symbol ICOS
Entrez Gene 29851
Alt Symbol AILIM, CD278, CVID1
Species Human
Gene Type protein-coding
Description inducible T-cell co-stimulator
Other Description activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator
Swissprots Q9Y6W8 Q8N6W8
Accessions AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 CAD59742 CAI53650 CAI53651 CAX87085 CBX47663 CBX51258 EAW70355 EAW70356 EAW70357 Q9Y6W8 AB023135 BAA82129 AJ277832 CAC06612 AK314985 BAG37484 BC028006 AAH28006 BC028210 AAH28210 CB528580 HQ448206 ADQ32686 XM_011511028 XP_011509330 XM_011511029 XP_011509331 XM_011511030 XP_011509332 XM_011511031 XP_011509333 NM_012092 NP_036224
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.
Subcellular Location Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
Top Pathways T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Intestinal immune network for IgA production

ICOS (W-18) - sc-9553 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICOS (W-18): sc-9553. Western blot analysis of ICOS expression in BYDP whole cell lysate showing detection of ICOS dimer under non-reducing conditions.

ICOS (C-20) - sc-9554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ICOS (C-20): sc-9554. Western blot analysis of ICOS expression in non-transfected: sc-117752 (A) and human ICOS transfected: sc-114660 (B) 293T whole cell lysates.

ICOS (FL-199) - sc-25585 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ICOS (FL-199): sc-25585. Western blot analysis of ICOS expression in non-transfected: sc-117752 (A) and human ICOS transfected: sc-114660 (B) 293T whole cell lysates.

ICOS (ANC6C6-A3) - sc-65285 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
ICOS (ANC6C6-A3): sc-65285. Indirect FCM analysis of PMA-stimulated human peripheral blood leukocytes stained with ICOS (ANC6C6-A3), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Anti-ICOS antibody - ab175401 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of MCF7 cells using ab175401. Blue DAPI for nuclear staining.

Anti-ICOS antibody - ab111247 from Abcam

Prices $378.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab111247, at 3.75µg/ml, staining ICOS in formalin-fixed, paraffin-embedded Human Thymus tissue by Immunohistochemistry.

Anti-ICOS antibody - ab183870 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-ICOS antibody (ab183870) at 1/500 dilution + K562 whole cell lysate/extract at 30 µg

Anti-ICOS antibody - ab117094 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ICOS antibody - ab95480 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal

Anti-ICOS antibody [15-414] (Allophycocyanin) - ab95627 from Abcam

Prices $193.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone 15-414
Staining of normal Human peripheral blood cells with Mouse IgG2a k Isotype Control APC (left) or ab95627 (right). Cells in the lymphocyte (green histogram) or granulocyte (blue histogram) gate were used for analysis

Anti-ICOS antibody [EPR7114] - ab133680 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7114
All lanes : Anti-ICOS antibody [EPR7114] (ab133680) at 1/1000 dilutionLane 1 : Human tonsil lysateLane 2 : Jurkat cell lysateLane 3 : Mouse thymus lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-ICOS antibody [EPR7114] (Alexa Fluor® 488) - ab198550 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7114
ab198550 staining ICOS in Jurkat cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198550 at 1/50 dilution (shown in green). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-ICOS antibody [EPR7114] (Alexa Fluor® 647) - ab198553 from Abcam

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7114
ab198553 staining ICOS in Jurkat cells. The cells were fixed with 100% methanol (5min), permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M glycine in 0.1% PBS-Tween for 1h. The cells were then incubated overnight at +4°C with ab198553 at 1/100 dilution (shown in red). Nuclear DNA was labelled with DAPI (shown in blue).Image was taken with a confocal microscope (Leica-Microsystems, TCS SP8).

Anti-ICOS antibody [ISA-3], prediluted (PE/Cy7 ®) - ab155380 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone ISA-3
Flow Cytometric analysis of normal Human peripheral blood cells either unstimulated (blue histogram) or stimulated for 3 days with anti-CD3/CD28 (purple histogram); labeling ICOS with ab155380 at 0.125µg. Total viable cells were used for analysis.

Anti-ICOS antibody [SP98] - ab105227 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone SP98
ab105227, at 1/100 dilution, staining ICOS in formalin-fixed, paraffin-embedded Human reactive lymph node tissue by Immunohistochemistry.

Anti-ICOS antibody - N-terminal - ab156994 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-ICOS antibody - N-terminal (ab156994) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : Mouse spleen total cell extractLane 3 : Mouse liver total cell extract

Anti-ICOS / CD278 Antibody (clone ANC6C6-A3, Biotin) - LS-C36842 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone ANC6C6-A3

Anti-ICOS / CD278 Antibody (clone C398.4A) - LS-C40834 from LifeSpan Bioscience

Prices $305.00
Sizes 500 µg
Host Hamster
Clonality Monoclonal
Clone C398.4A
PHA-stimulated human peripheral blood lymphocytes (3 days) stained with purified C398.4A, followed by biotinylated anti-Armenian hamster IgG and Sav-PE

Anti-ICOS Antibody (clone 15F9, PE) - LS-C105975 from LifeSpan Bioscience

Prices $245.00
Sizes 50 µg
Host Hamster
Clonality Monoclonal
Clone 15F9
Surface staining of ConA stimulated splenocytes with anti-mouse ICOS (15F9) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Anti-ICOS / CD278 Antibody (clone ISA-3, FITC) - LS-C105881 from LifeSpan Bioscience

Prices $265.00, $365.00
Sizes 25 tst, 100 tst
Host Mouse
Clonality Monoclonal
Clone ISA-3
Staining of 3-day unstimulated (left) and 3-day anti-CD3/CD28 stimulated (right) human peripheral blood cells with FITC Mouse IgG1, K Isotype Control (blue histogram) or FITC anti-human ICOS (purple histogram). Cells in the lymphocyte gate were used for analysis.

Anti-ICOS / CD278 Antibody - LS-C123801 from LifeSpan Bioscience

Prices $435.00
Sizes 250 µg
Host Hamster
Clonality Monoclonal

Anti-ICOS / CD278 Antibody (clone 7E.17G9, PE, Cy5) - LS-C107420 from LifeSpan Bioscience

Prices $275.00, $355.00
Sizes 50 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 7E.17G9
Surface staining of ConA stimulated splenocytes with anti-mouse ICOS (7E.17G9) PE. Appropriate isotype controls were used (open histogram). Total viable cells were used for analysis.

Anti-ICOS / CD278 Antibody (aa156-185) - LS-C100393 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human lymph with ICOS Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-ICOS / CD278 Antibody (clone ISA-3, Biotin) - LS-C106719 from LifeSpan Bioscience

Prices $235.00, $395.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone ISA-3
Staining of 2-day CD3/CD28 activated PBMC with Biotin Mouse IgG1, K isotype control (open histogram) or Biotin ISA-3 (colored histogram) followed by SAv-PE. Total viable cells were used for analysis.

Anti-ICOS / CD278 Antibody (clone ANC6C6-A3) - LS-C134607 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone ANC6C6-A3
Flow cytometry of ICOS antibody
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