ICOS

Gene Symbol	ICOS
Entrez Gene	29851
Alt Symbol	AILIM, CD278, CVID1
Species	Human
Gene Type	protein-coding
Description	inducible T-cell co-stimulator
Other Description	activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator
Swissprots	Q9Y6W8 Q8N6W8
Accessions	AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 CAD59742 CAI53650 CAI53651 CAX87085 CBX47663 CBX51258 EAW70355 EAW70356 EAW70357 Q9Y6W8 AB023135 BAA82129 AJ277832 CAC06612 AK314985 BAG37484 BC028006 AAH28006 BC028210 AAH28210 CB528580 HQ448206 ADQ32686 XM_011511028 XP_011509330 XM_011511029 XP_011509331 XM_011511030 XP_011509332 XM_011511031 XP_011509333 NM_012092 NP_036224
Function	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ICOS / CD278 ELISA Kit (Sandwich ELISA) - LS-F6591 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 15.63 pg/ml Range 0.411-100 ng/ml

Human ICOS DuoSet ELISA - DY169 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 78.10 - 5,000 pg/mL

Human ICOS ELISA Kit - abx151895 from Abbexa Category ELISA Kit Sensitivity 6.3 pg/ml Range 15.625 pg/ml - 1000 pg/ml

Inducible T-Cell Co Stimulator (ICOS), Human, ELISA Kit - SEA777Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 6.2pg/mL Range 15.6-1,000pg/mL

Inducible T-cell Costimulator, Human, ELISA Kit - E01I0046 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

Human ICOS ELISA - ELH-ICOS from RayBiotech Category ELISA Kit Prices $462.00, $832.00, $1,850.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 1.2 ng/ml Range 1.2 ng/ml - 300 ng/ml

Immunoglobulin G4 (IgG4) , ELISA Kit - MBS705565 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.8 ng/ml. Range 7.8 ng/ml -500 ng/ml.

Immunoglobulin G4 (IgG4), ELISA Kit - MBS703648 from MyBioSource Category ELISA Kit Prices $250.00, $435.00, $625.00, $2,595.00, $4,905.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T cell Costimulator, ELISA Kit - MBS746407 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-Cell Co Stimulator (ICOS), ELISA Kit - MBS2020489 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <5.8pg/mL Range 15.6-1,000pg/mL

Inducible T-Cell Co Stimulator Ligand (ICOSLG), ELISA Kit - MBS2024345 from MyBioSource Category ELISA Kit Prices $345.00, $515.00, $695.00, $2,840.00, $5,180.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.063ng/mL. Range 0.156-10ng/mL

Inducible T-cell Costimulator, ELISA Kit - MBS751622 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Inducible T-cell Costimulator, ELISA Kit - MBS745243 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS750627 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Inducible T-cell Costimulator, ELISA Kit - MBS752987 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS749662 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS748387 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS753545 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS744340 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Inducible T-cell Costimulator, ELISA Kit - MBS753820 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS751321 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Inducible T-cell Costimulator, ELISA Kit - MBS749290 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) - SEA777Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.1pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

ELISA Kit for Inducible T-Cell Co Stimulator (ICOS) - SEA777Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.1pg/mL. Range 15.625-1000pg/mL The standard curve concentrations used for the ELISA's were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.625pg/mL

Human ICOS / CD278 ELISA Kit (Sandwich ELISA) - LS-F3606 from LifeSpan Bioscience Category ELISA Kit Prices $520.00, $920.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.411 ng/ml Range 0.411-100 ng/ml

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