| Gene Symbol | ICOS |
|---|---|
| Entrez Gene | 29851 |
| Alt Symbol | AILIM, CD278, CVID1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | inducible T-cell co-stimulator |
| Other Description | activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator |
| Swissprots | Q9Y6W8 Q8N6W8 |
| Accessions | AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 CAD59742 CAI53650 CAI53651 CAX87085 CBX47663 CBX51258 EAW70355 EAW70356 EAW70357 Q9Y6W8 AB023135 BAA82129 AJ277832 CAC06612 AK314985 BAG37484 BC028006 AAH28006 BC028210 AAH28210 CB528580 HQ448206 ADQ32686 XM_011511028 XP_011509330 XM_011511029 XP_011509331 XM_011511030 XP_011509332 XM_011511031 XP_011509333 NM_012092 NP_036224 |
| Function | Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}. |
| Subcellular Location | Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
| Tissue Specificity | Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}. |
| Top Pathways | T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Intestinal immune network for IgA production |
ICOS CRISPR/Cas9 KO Plasmid (h) - sc-417635 from Santa Cruz Biotechnology
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ICOS HDR Plasmid (h) - sc-417635-HDR from Santa Cruz Biotechnology
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ICOS Double Nickase Plasmid (h) - sc-417635-NIC from Santa Cruz Biotechnology
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ICOS Double Nickase Plasmid (h2) - sc-417635-NIC-2 from Santa Cruz Biotechnology
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ICOS CRISPR Activation Plasmid (h) - sc-417635-ACT from Santa Cruz Biotechnology
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ICOS CRISPR Activation Plasmid (h2) - sc-417635-ACT-2 from Santa Cruz Biotechnology
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ICOS Lentiviral Activation Particles (h) - sc-417635-LAC from Santa Cruz Biotechnology
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ICOS Lentiviral Activation Particles (h2) - sc-417635-LAC-2 from Santa Cruz Biotechnology
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ICOS siRNA (h) - sc-42770 from Santa Cruz Biotechnology
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ICOS shRNA Plasmid (h) - sc-42770-SH from Santa Cruz Biotechnology
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ICOS shRNA (h) Lentiviral Particles - sc-42770-V from Santa Cruz Biotechnology
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ICOS RNAi - H00029851-R01 from Novus Biologicals
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MISSION® esiRNA - EHU019561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10433 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10433 from Sigma-Aldrich
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ICOS siRNA (Human) - CRH9241 from Cohesion Biosciences
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ICOS - MBS8229595 from MyBioSource
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shRNA set against Human ICOS (NM_012092.3) - SHH316453 from Creative biogene
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Human ICOS siRNA - orb269743 from Biorbyt
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ICOS shRNA Plasmid (Human) - CHH9241 from Cohesion Biosciences
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ICOS miRNA 3'UTR clone - MiUTR4H-TG04387 from Creative biogene
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