ICOS

Gene Symbol	ICOS
Entrez Gene	29851
Alt Symbol	AILIM, CD278, CVID1
Species	Human
Gene Type	protein-coding
Description	inducible T-cell co-stimulator
Other Description	activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator
Swissprots	Q9Y6W8 Q8N6W8
Accessions	AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 CAD59742 CAI53650 CAI53651 CAX87085 CBX47663 CBX51258 EAW70355 EAW70356 EAW70357 Q9Y6W8 AB023135 BAA82129 AJ277832 CAC06612 AK314985 BAG37484 BC028006 AAH28006 BC028210 AAH28210 CB528580 HQ448206 ADQ32686 XM_011511028 XP_011509330 XM_011511029 XP_011509331 XM_011511030 XP_011509332 XM_011511031 XP_011509333 NM_012092 NP_036224
Function	Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.
Subcellular Location	Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity	Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Intestinal immune network for IgA production

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ICOS full length protein - ab153306 from Abcam Category Protein Source Wheat germ Species Human

Human ICOS protein fragment - ab153307 from Abcam Category Protein Source Wheat germ Species Human

ICOS / CD278 Antibody Blocking Peptide - LS-E8095 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ICOS / CD278 Antibody Blocking Peptide - LS-E27110 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ICOS Protein - H00029851-P01 from Novus Biologicals Category Protein Prices $319.00, $529.00 Sizes 2 µg, 25 µg Source Wheat Germ Species Human

ICOS Peptide - P1753 from Novus Biologicals Category Peptide Species Human

Recombinant Human ICOS Protein - H00029851-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

ICOS-Antibody-C-term-Blocking-Peptide - BP6146a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ICOS blocking peptide - GTX88315-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

Recombinant Human ICOS Fc Chimera, CF - 169-CS-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human ICOS Fc His tag protein - orb83632 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Human ICOS protein - orb180294 from Biorbyt Category Protein Prices $306.00, $400.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human ICOS Protein - abx067182 from Abbexa Category Protein Source E.coli Species Human

ICOS Peptide - AC21-1931-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD278 / ICOS - H00029851-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD278 / ICOS - H00029851-P01-10 from Acris Antibodies Category Protein Source in vitro transl. Species Human

CD278 / ICOS - H00029851-P01-25 from Acris Antibodies Category Protein Source in vitro transl. Species Human

CD278 / ICOS - H00029851-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD278 / ICOS - H00029851-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Inducible T-Cell Co Stimulator (ICOS), Human - 20-7088 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Human

ICOS Peptide - 42-123P from ProSci Category Peptide

ICOS fusion protein - ag4155 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human ICOS, Fc-His tagged - ICOS-3243H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human ICOS protein - ICOS-1628H from Creative Biomart Category Protein Source NS0 Species Human

Recombinant Human ICOS, Fc-tagged - ICOS-185H from Creative Biomart Category Protein Source CHO Cells Species Human

Search more