| Gene Symbol |
ICOS
|
| Entrez Gene |
29851
|
| Alt Symbol |
AILIM, CD278, CVID1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inducible T-cell co-stimulator
|
| Other Description |
activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator
|
| Swissprots |
Q9Y6W8 Q8N6W8
|
| Accessions |
AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 CAD59742 CAI53650 CAI53651 CAX87085 CBX47663 CBX51258 EAW70355 EAW70356 EAW70357 Q9Y6W8 AB023135 BAA82129 AJ277832 CAC06612 AK314985 BAG37484 BC028006 AAH28006 BC028210 AAH28210 CB528580 HQ448206 ADQ32686 XM_011511028 XP_011509330 XM_011511029 XP_011509331 XM_011511030 XP_011509332 XM_011511031 XP_011509333 NM_012092 NP_036224
|
| Function |
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
|
| Top Pathways |
T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Intestinal immune network for IgA production
|
