ICOS

Gene Symbol ICOS
Entrez Gene 29851
Alt Symbol AILIM, CD278, CVID1
Species Human
Gene Type protein-coding
Description inducible T-cell co-stimulator
Other Description activation-inducible lymphocyte immunomediatory molecule|inducible T-cell costimulator|inducible costimulator
Swissprots Q9Y6W8 Q8N6W8
Accessions AAL40933 AAL40934 AAM00909 AAX93073 ABK41910 CAD59742 CAI53650 CAI53651 CAX87085 CBX47663 CBX51258 EAW70355 EAW70356 EAW70357 Q9Y6W8 AB023135 BAA82129 AJ277832 CAC06612 AK314985 BAG37484 BC028006 AAH28006 BC028210 AAH28210 CB528580 HQ448206 ADQ32686 XM_011511028 XP_011509330 XM_011511029 XP_011509331 XM_011511030 XP_011509332 XM_011511031 XP_011509333 NM_012092 NP_036224
Function Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up- regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up- regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre- activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250}.
Subcellular Location Isoform 1: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissue Specificity Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B- cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. {ECO:0000269|PubMed:11006126, ECO:0000269|PubMed:11169414, ECO:0000269|PubMed:9930702}.
Top Pathways T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Primary immunodeficiency, Intestinal immune network for IgA production

Human-ICOS-cDNA-Clone - DC05744 from Abgent, a WuXi AppTec company

Prices $226.80
Sizes 10 µg
Species Human
Accession BC028006

Human ICOS (NP_036224) VersaClone cDNA - RDC0751 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Human

Mouse ICOS (NP_059508) VersaClone cDNA - RDC0775 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Mouse

Human ICOS ORF Clone(NM_012092.3) - CDCL166752 from Creative Biomart

Species Human
Accession NM_012092.3

Human ICOS ORF Clone(NM_012092.3) - CDCL166753 from Creative Biomart

Species Human
Accession NM_012092.3

Human ICOS Gene cDNA clone plasmid - HG10344-M from Sino Biological

Species Human

Human ICOS ORF Clone (BC028006) - CDCS413191 from Creative biogene

Species Human
Accession Q9Y6W8

Human ICOS ORF Clone (BC028210) - CDCS413192 from Creative biogene

Species Human
Accession Q9Y6W8

Human ICOS ORF clone (NM_012092.2) - CDCB157471 from Creative biogene

Species Human

Human ICOS gene - orb90931 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Human

Cynomolgus Monkey ICOS (XP_005574075) VersaClone cDNA - RDC1851 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Monkey
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