| Gene Symbol |
MRI1
|
| Entrez Gene |
84245
|
| Alt Symbol |
MRDI, MTNA, Ypr118w
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
methylthioribose-1-phosphate isomerase 1
|
| Other Description |
M1Pi|MTR-1-P isomerase|S-methyl-5-thioribose-1-phosphate isomerase 1|mediator of RhoA-dependent invasion|methylthioribose-1-phosphate isomerase|methylthioribose-1-phosphate isomerase homolog|translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
|
| Swissprots |
Q8NDC9 Q9BV20
|
| Accessions |
EAW84369 EAW84370 EAW84371 Q9BV20 AF318324 AAL55831 AL834276 CAD38951 AM392616 CAL37494 AM393224 CAL38102 AY358176 AAQ88543 BC001703 AAH01703 BM147362 EU832338 ACE87595 EU832423 ACE86908 HQ448241 ADQ32721 XM_011528355 XP_011526657 XM_011528356 XP_011526658 XM_011528357 XP_011526659 XR_244089 NM_001031727 NP_001026897 NM_032285 NP_115661
|
| Function |
Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}.
|
| Subcellular Location |
Nucleus {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cytoplasm {ECO:0000255|HAMAP- Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cell projection {ECO:0000269|PubMed:19620624}. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
|
| Top Pathways |
Cysteine and methionine metabolism
|