MRI1

Gene Symbol MRI1
Entrez Gene 84245
Alt Symbol MRDI, MTNA, Ypr118w
Species Human
Gene Type protein-coding
Description methylthioribose-1-phosphate isomerase 1
Other Description M1Pi|MTR-1-P isomerase|S-methyl-5-thioribose-1-phosphate isomerase 1|mediator of RhoA-dependent invasion|methylthioribose-1-phosphate isomerase|methylthioribose-1-phosphate isomerase homolog|translation initiation factor eIF-2B subunit alpha/beta/delta-like protein
Swissprots Q8NDC9 Q9BV20
Accessions EAW84369 EAW84370 EAW84371 Q9BV20 AF318324 AAL55831 AL834276 CAD38951 AM392616 CAL37494 AM393224 CAL38102 AY358176 AAQ88543 BC001703 AAH01703 BM147362 EU832338 ACE87595 EU832423 ACE86908 HQ448241 ADQ32721 XM_011528355 XP_011526657 XM_011528356 XP_011526658 XM_011528357 XP_011526659 XR_244089 NM_001031727 NP_001026897 NM_032285 NP_115661
Function Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}.
Subcellular Location Nucleus {ECO:0000255|HAMAP-Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cytoplasm {ECO:0000255|HAMAP- Rule:MF_03119, ECO:0000269|PubMed:19620624}. Cell projection {ECO:0000269|PubMed:19620624}. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.
Top Pathways Cysteine and methionine metabolism

MRI1 CRISPR/Cas9 KO Plasmid (h) - sc-413588 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 HDR Plasmid (h) - sc-413588-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 Double Nickase Plasmid (h) - sc-413588-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 Double Nickase Plasmid (h2) - sc-413588-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 CRISPR Activation Plasmid (h) - sc-413588-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 CRISPR Activation Plasmid (h2) - sc-413588-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 Lentiviral Activation Particles (h) - sc-413588-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 Lentiviral Activation Particles (h2) - sc-413588-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MRI1 siRNA (h) - sc-97714 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRI1 shRNA Plasmid (h) - sc-97714-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MRI1 shRNA (h) Lentiviral Particles - sc-97714-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU149401 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14540 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14540 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MRI1 siRNA (Human) - CRJ3373 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EI2BL RNAi - H00084245-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EI2BL RNAi - H00084245-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human MRI1 (NM_032285.2) - SHH344448 from Creative biogene

Category siRNA
Species Reactivities Human

Human MRI1 siRNA - orb273874 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MRI1 shRNA Plasmid (Human) - CHJ3373 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MRI1 miRNA 3'UTR clone - MiUTR1H-06270 from Creative biogene

Species Reactivities Human

MRI1 miRNA 3'UTR clone - MiUTR1H-06271 from Creative biogene

Species Reactivities Human
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