| Gene Symbol |
SAMHD1
|
| Entrez Gene |
25939
|
| Alt Symbol |
CHBL2, DCIP, HDDC1, MOP-5, SBBI88
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SAM domain and HD domain 1
|
| Other Description |
SAM domain and HD domain-containing protein 1|dNTPase|dendritic cell-derived IFNG-induced protein|deoxynucleoside triphosphate triphosphohydrolase SAMHD1|monocyte protein 5
|
| Swissprots |
Q9Y3Z3 Q9H005 E1P5V2 Q5JXG8 Q9H004 Q9H3U9 B4E2A5 Q8N491
|
| Accessions |
EAW76090 EAW76091 Q9Y3Z3 AB013847 BAB18916 AB208944 BAD92181 AF228421 AAF32407 AK027811 BAB55386 AK304187 BAG65067 AK304795 BAG65545 AK311150 AK315169 AL050267 CAB43368 BC036450 AAH36450 CA392465 DA351335 JF432320 ADZ15537 XM_005260384 XP_005260441 XM_011528761 XP_011527063 NM_015474 NP_056289
|
| Function |
Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. {ECO:0000269|PubMed:18546154, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:24336198}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:23092512}.
|
| Tissue Specificity |
Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus. {ECO:0000269|PubMed:11064105}.
|
![Western Blot: SAMHD1 Overexpression Lysate (Adult Normal) [NBL1-15682] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SAMHD1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/4232_SAMHD1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15682-img0002.jpg)