SAMHD1

Gene Symbol SAMHD1
Entrez Gene 25939
Alt Symbol CHBL2, DCIP, HDDC1, MOP-5, SBBI88
Species Human
Gene Type protein-coding
Description SAM domain and HD domain 1
Other Description SAM domain and HD domain-containing protein 1|dNTPase|dendritic cell-derived IFNG-induced protein|deoxynucleoside triphosphate triphosphohydrolase SAMHD1|monocyte protein 5
Swissprots Q9Y3Z3 Q9H005 E1P5V2 Q5JXG8 Q9H004 Q9H3U9 B4E2A5 Q8N491
Accessions EAW76090 EAW76091 Q9Y3Z3 AB013847 BAB18916 AB208944 BAD92181 AF228421 AAF32407 AK027811 BAB55386 AK304187 BAG65067 AK304795 BAG65545 AK311150 AK315169 AL050267 CAB43368 BC036450 AAH36450 CA392465 DA351335 JF432320 ADZ15537 XM_005260384 XP_005260441 XM_011528761 XP_011527063 NM_015474 NP_056289
Function Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. {ECO:0000269|PubMed:18546154, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:24336198}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:23092512}.
Tissue Specificity Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus. {ECO:0000269|PubMed:11064105}.

SAMHD1 Antibody - 12361 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using SAMHD1 Antibody.

SAMHD1 (D-14) - sc-86212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SAMHD1 (D-14): sc-86212. Immunoperoxidase staining of formalin fixed, paraffin-embedded human appendix tissue showing cytoplasmic and membrane staining of glandular cells and lymphoid tissue.

SAMHD1 (N-17) - sc-86213 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SAMHD1 [EPR13034] antibody - N-terminal - ab191420 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13034
Anti-SAMHD1 [EPR13034] antibody - N-terminal (ab191420) at 1/10000 dilution + THP1 cell lysate at 20 µgSecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-SAMHD1 antibody - ab67820 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-SAMHD1 antibody (ab67820) at 1/500 dilution + human liver tissue lysate at 25 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-SAMHD1 antibody - ab192595 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAMHD1 antibody (ab192595) at 1/1000 dilutionLane 1 : HepG2 l(Human liver hepatocellular carcinoma) cell lysateLane 2 : HeLa (Human epithelial cells from cervix adenocarcinoma) cell lysateLane 3 : THP-1 (Human monocytic leukemia cells) cell lysateLane 4 : MCF7 (Human breast adenocarcinoma cell line) cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-SAMHD1 antibody - ab96768 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SAMHD1 antibody (ab96768) at 1/500 dilution + Raji whole cell lysate at 30 µg

Anti-SAMHD1 antibody - ab83982 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SAMHD1 antibody (ab83982) at 1 µg/ml (in 5% skim milk / PBS buffer) + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-SAMHD1 antibody - ab173174 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SAMHD1 antibody (ab173174) at 1/100 dilution + K562 cell lysate at 35 µg

Anti-SAMHD1 antibody - ab134234 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SAMHD1 antibody (ab134234) at 1 µg/mlLane 1 : Human heart tissue lysate Lane 2 : Human heart tissue lysate with immunizing peptideLysates/proteins at 20 µg per lane.SecondaryGoat anti-Rabbit Ig HRPdeveloped using the ECL technique

Anti-SAMHD1 antibody [1A1] - ab128107 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A1
All lanes : Anti-SAMHD1 antibody [1A1] (ab128107) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cells transfected with pCMV6-ENTRY SAMHD1 cDNALysates/proteins at 5 µg per lane.

Anti-SAMHD1 antibody [1F9] - ab117908 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F9
Flow cytometric Analysis of Hela cells, using anti-SAMHD1 antibody (ab117908) (Red), compared to a nonspecific negative control antibody (Blue).

Anti-SAMHD1 antibody [3B9] - ab119683 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3B9
All lanes : Anti-SAMHD1 antibody [3B9] (ab119683) at 1/2000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY SAMHD1 cDNALysates/proteins at 5 µg per lane.

Anti-SAMHD1 antibody [3F5] - ab119751 from Abcam

Prices $385.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3F5
All lanes : Anti-SAMHD1 antibody [3F5] (ab119751) at 1/200 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY control Lane 2 : HEK293T cells transfected with pCMV6-ENTRY SAMHD1 cDNALysates/proteins at 5 µg per lane.

Anti-SAMHD1 antibody [EPR13040(B)] - C-terminal - ab177462 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13040(B)
Flow cytometric analysis of permeabilized THP1 cells labeling SAMHD1 (red) with ab177462 at 1/10 dilution or  rabbit IgG (negative) (green).

Anti-SAMHD1 antibody [GT954] - ab184541 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone GT954
All lanes : Anti-SAMHD1 antibody [GT954] (ab184541) at 1/1000 dilutionLane 1 : THP1 whole cell lysateLane 2 : NCI-H929 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-SAMHD1 Antibody (clone 2A5) - LS-C172429 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2A5
IHC of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SAMHD1 mouse monoclonal antibody.

Anti-SAMHD1 Antibody (clone 3F5) IHC-plus™ - LS-B9640 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 3F5
Anti-SAMHD1 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B9640 concentration 5 ug/ml.

Anti-SAMHD1 Antibody (aa288-337) - LS-C102605 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SAMHD1 antibody LS-C102605 Western blot of HepG2 cell lysate.

Anti-SAMHD1 Antibody (aa203-230, AP) - LS-C223979 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAMHD1 Antibody (aa203-230, APC) - LS-C223980 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAMHD1 Antibody (aa203-230, FITC) - LS-C223982 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAMHD1 Antibody (aa203-230, Biotin) - LS-C223981 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAMHD1 Antibody (aa203-230, Azide-free, HRP) - LS-C223983 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SAMHD1 Antibody (aa203-230, PE) - LS-C223986 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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