SAMHD1

Gene Symbol SAMHD1
Entrez Gene 25939
Alt Symbol CHBL2, DCIP, HDDC1, MOP-5, SBBI88
Species Human
Gene Type protein-coding
Description SAM domain and HD domain 1
Other Description SAM domain and HD domain-containing protein 1|dNTPase|dendritic cell-derived IFNG-induced protein|deoxynucleoside triphosphate triphosphohydrolase SAMHD1|monocyte protein 5
Swissprots Q9Y3Z3 Q9H005 E1P5V2 Q5JXG8 Q9H004 Q9H3U9 B4E2A5 Q8N491
Accessions EAW76090 EAW76091 Q9Y3Z3 AB013847 BAB18916 AB208944 BAD92181 AF228421 AAF32407 AK027811 BAB55386 AK304187 BAG65067 AK304795 BAG65545 AK311150 AK315169 AL050267 CAB43368 BC036450 AAH36450 CA392465 DA351335 JF432320 ADZ15537 XM_005260384 XP_005260441 XM_011528761 XP_011527063 NM_015474 NP_056289
Function Host restriction nuclease that blocks early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity. May function by reducing the cellular dNTP levels to levels too low for retroviral reverse transcription to occur. May play a role in mediating proinflammatory responses to TNF-alpha signaling. {ECO:0000269|PubMed:18546154, ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:22056990, ECO:0000269|PubMed:24336198}.
Subcellular Location Nucleus {ECO:0000269|PubMed:19525956, ECO:0000269|PubMed:23092512}.
Tissue Specificity Expressed in heart, skeletal muscle, spleen, liver, small intestine, placenta, lung and peripheral blood leukocytes. No expression is seen in brain and thymus. {ECO:0000269|PubMed:11064105}.

SAMHD1 CRISPR/Cas9 KO Plasmid (h) - sc-406002 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 HDR Plasmid (h) - sc-406002-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 Double Nickase Plasmid (h) - sc-406002-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 Double Nickase Plasmid (h2) - sc-406002-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 CRISPR Activation Plasmid (h) - sc-406002-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 CRISPR Activation Plasmid (h2) - sc-406002-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 Lentiviral Activation Particles (h) - sc-406002-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 Lentiviral Activation Particles (h2) - sc-406002-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SAMHD1 siRNA (h) - sc-76442 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SAMHD1 shRNA Plasmid (h) - sc-76442-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SAMHD1 shRNA (h) Lentiviral Particles - sc-76442-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU003851 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18839 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18839 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05763 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05763

SAMHD1 siRNA (Human) - CRH8603 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SAMHD1 - MBS8239941 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SAMHD1 (NM_015474.3) - SHH401732 from Creative biogene

Category siRNA
Species Reactivities Human

Human SAMHD1 siRNA - orb269105 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SAMHD1 shRNA Plasmid (Human) - CHH8603 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SAMHD1 miRNA 3'UTR clone - MiUTR3H-08695 from Creative biogene

Species Reactivities Human
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