KARS

Gene Symbol	KARS
Entrez Gene	3735
Alt Symbol	CMTRIB, DFNB89, KARS1, KARS2, KRS
Species	Human
Gene Type	protein-coding
Description	lysyl-tRNA synthetase
Other Description	lysRS|lysine tRNA ligase|lysine--tRNA ligase
Swissprots	D3DUK4 Q96J25 O14946 Q9HB23 Q15046 A8MSK1
Accessions	EAW95619 EAW95620 EAW95621 EAW95622 EAW95623 EAW95624 Q15046 AA503390 AF285758 AAG30114 AK126584 BAC86604 AK309168 AK315687 BC004132 AAH04132 BC013246 BM781594 D31890 BAA06688 D32053 BAA22084 DQ892301 ABM83227 DQ895500 ABM86426 NM_001130089 NP_001123561 NM_005548 NP_005539
Function	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:5338216}.
Subcellular Location	Isoform Cytoplasmic: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted. Note=Secretion is induced by TNF-alpha.
Top Pathways	Aminoacyl-tRNA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KARS ELISA Kit (Sandwich ELISA) - LS-F6660 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.117 ng/ml Range 0.313-20 ng/ml

Mouse KARS ELISA Kit (Sandwich ELISA) - LS-F6661 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 11.7 pg/ml Range 0.313-20 ng/ml

Lysyl tRNA Synthetase (KARS), Human, ELISA Kit - SED002Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.082 ng/mL Range 0.312-20 ng/mL

Lysyl-tRNA synthetase, KARS, Human, ELISA Kit - E0187h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Lysyl tRNA Synthetase (KARS), ELISA Kit - MBS2023685 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 11.7pg/mL. Range 31.2-2,000pg/mL. The standard curve concentrations used for the ELISA's were 2,000pg/mL, 1,000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.2pg/mL.

Lysyl tRNA Synthetase (KARS), ELISA Kit - MBS2023187 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.117ng/mL. Range 0.312-20ng/mL. The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL.

Lysyl-tRNA Synthetase, ELISA Kit - MBS494883 from MyBioSource Category ELISA Kit Prices $835.00 Sizes 96 tests Sensitivity The minimum detectable dose of KRS was determined by two standard deviations to the mean value of 20 blank samples. The minimum detectable dose of human KRS using a standard curve generated is 1.7 ng/ml.

ELISA Kit for Lysyl tRNA Synthetase (KARS) - SED002Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Lysyl tRNA Synthetase (KARS) - SED002Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 11.7pg/mL. Range 31.25-2000pg/mL The standard curve concentrations used for the ELISA’s were 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL

ELISA Kit for Lysyl tRNA Synthetase (KARS) - SED002Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.117ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Mouse KARS ELISA Kit (Custom ELISA) - LS-F13945 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Human KARS ELISA Kit (Custom ELISA) - LS-F13946 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.313-20 ng/ml

Lysyl tRNA Synthetase (KARS), Human, ELISA Kit - DL-KARS-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.312-20 ng/mL

Human KARS ELISA Kit - abx572406 from Abbexa Category ELISA Kit Sensitivity 0.082 ng/ml Range 0.313 ng/ml - 20 ng/ml

Human KARS ELISA Kit - E023317 from Biobool Category ELISA Kit Sensitivity The minimum detectable dose of KRS was determined by two standard deviations to the mean value of 20 blank samples. The minimum detectable dose of human KRS using a standard curve generated is 1.7 ng/ml.

KARS ELISA Kit (Human) (OKCD00889) - OKCD00889 from Aviva Systems Biology Category ELISA Kit Prices $545.00 Sizes 96 wells Sensitivity < 0.117 ng/mL Range 0.312-20 ng/mL

Lysyl tRNA Synthetase (KARS), ELISA Kit - MBS454113 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.082ng/mL Range 0.312-20ng/mL

Lysyl-tRNA synthetase, ELISA Kit - MBS2882672 from MyBioSource Category ELISA Kit Prices $380.00, $500.00, $2,170.00, $3,840.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Lysyl tRNA Synthetase, ELISA Kit - MBS2533484 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

Lysyl tRNA Synthetase, ELISA Kit - MBS764100 from MyBioSource Category ELISA Kit Prices $295.00, $390.00, $1,615.00, $3,015.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/ml Range 62.5-4000pg/ml

Lysyl tRNA Synthetase (KARS), ELISA Kit - MBS9370223 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

KARS ELISA Kit (Human) (OKEH07021) - OKEH07021 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.312 ng/mL Range 0.313 - 20 ng/mL

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