KARS

Gene Symbol KARS
Entrez Gene 3735
Alt Symbol CMTRIB, DFNB89, KARS1, KARS2, KRS
Species Human
Gene Type protein-coding
Description lysyl-tRNA synthetase
Other Description lysRS|lysine tRNA ligase|lysine--tRNA ligase
Swissprots D3DUK4 Q96J25 O14946 Q9HB23 Q15046 A8MSK1
Accessions EAW95619 EAW95620 EAW95621 EAW95622 EAW95623 EAW95624 Q15046 AA503390 AF285758 AAG30114 AK126584 BAC86604 AK309168 AK315687 BC004132 AAH04132 BC013246 BM781594 D31890 BAA06688 D32053 BAA22084 DQ892301 ABM83227 DQ895500 ABM86426 NM_001130089 NP_001123561 NM_005548 NP_005539
Function Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:5338216}.
Subcellular Location Isoform Cytoplasmic: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted. Note=Secretion is induced by TNF-alpha.
Top Pathways Aminoacyl-tRNA biosynthesis

LysRS CRISPR/Cas9 KO Plasmid (h) - sc-404110 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS HDR Plasmid (h) - sc-404110-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS Double Nickase Plasmid (h) - sc-404110-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS Double Nickase Plasmid (h2) - sc-404110-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS CRISPR Activation Plasmid (h) - sc-404110-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS CRISPR Activation Plasmid (h2) - sc-404110-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS Lentiviral Activation Particles (h) - sc-404110-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS Lentiviral Activation Particles (h2) - sc-404110-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LysRS siRNA (h) - sc-75718 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LysRS shRNA Plasmid (h) - sc-75718-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LysRS shRNA (h) Lentiviral Particles - sc-75718-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Lysyl tRNA synthetase RNAi - H00003735-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU080701 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10894 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10894 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00883 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00883

KARS siRNA (Human) - CRH2512 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

KARS, siRNA - MBS8231854 from MyBioSource

Category siRNA
Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KARS (NM_005548.2) - SHH322403 from Creative biogene

Category siRNA
Species Reactivities Human

KARS shRNA Plasmid (Human) - CHH2512 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KARS miRNA 3'UTR clone - MiUTR3H-04110 from Creative biogene

Species Reactivities Human

KARS miRNA 3'UTR clone - MiUTR3H-04111 from Creative biogene

Species Reactivities Human
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