KARS

Gene Symbol	KARS
Entrez Gene	3735
Alt Symbol	CMTRIB, DFNB89, KARS1, KARS2, KRS
Species	Human
Gene Type	protein-coding
Description	lysyl-tRNA synthetase
Other Description	lysRS|lysine tRNA ligase|lysine--tRNA ligase
Swissprots	D3DUK4 Q96J25 O14946 Q9HB23 Q15046 A8MSK1
Accessions	EAW95619 EAW95620 EAW95621 EAW95622 EAW95623 EAW95624 Q15046 AA503390 AF285758 AAG30114 AK126584 BAC86604 AK309168 AK315687 BC004132 AAH04132 BC013246 BM781594 D31890 BAA06688 D32053 BAA22084 DQ892301 ABM83227 DQ895500 ABM86426 NM_001130089 NP_001123561 NM_005548 NP_005539
Function	Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:5338216}.
Subcellular Location	Isoform Cytoplasmic: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted. Note=Secretion is induced by TNF-alpha.
Top Pathways	Aminoacyl-tRNA biosynthesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Lysyl tRNA synthetase full length protein - ab185600 from Abcam Category Protein Source E. coli Species Human

Human Lysyl tRNA synthetase full length protein - ab132383 from Abcam Category Protein Source Wheat germ Species Human

Human Lysyl tRNA synthetase protein fragment - ab113142 from Abcam Category Protein Source E. coli Species Human

KARS Antibody Blocking Peptide - LS-E739 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KARS Antibody Blocking Peptide - LS-E14838 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Lysyl tRNA synthetase Recombinant Protein - H00003735-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Lysyl tRNA synthetase Protein - NBP1-72410 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

KARS-Antibody-N-term-Blocking-peptide - BP11097a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human KARS protein - orb168685 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

KARS Blocking Peptide - 33R-3434 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KARS protein (His tag) - 80R-1927 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

KARS (63-597, His-tag) - AR39106PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

KARS (63-597, His-tag) - AR39106PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

KARS - H00003735-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KARS - H00003735-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Lysyl-tRNA Synthetase, Human Recombinant - 228-12312-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Lysyl-tRNA Synthetase Human - 228-12312-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Lysyl-tRNA Synthetase Human - 228-12312-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

KARS, 63-597aa, Human, His tag, E.coli - 01-P1166 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

KARS fusion protein - Ag6778 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

KARS Human - ENPS-168 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Lysyl-tRNA Synthetase Enzyme - BP002783-ENZ-161 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 20 µg, 1 mg Source E. coli-derived. Species Human

KARS, 63-597aa, Recombinant Protein - GWB-P0872A from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human KARS, His-tagged - KARS-1010H from Creative Biomart Category Protein

Recombinant Human KARS, His-tagged - KARS-29008TH from Creative Biomart Category Protein Source E. coli Species Human

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