| Gene Symbol |
KARS
|
| Entrez Gene |
3735
|
| Alt Symbol |
CMTRIB, DFNB89, KARS1, KARS2, KRS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysyl-tRNA synthetase
|
| Other Description |
lysRS|lysine tRNA ligase|lysine--tRNA ligase
|
| Swissprots |
D3DUK4 Q96J25 O14946 Q9HB23 Q15046 A8MSK1
|
| Accessions |
EAW95619 EAW95620 EAW95621 EAW95622 EAW95623 EAW95624 Q15046 AA503390 AF285758 AAG30114 AK126584 BAC86604 AK309168 AK315687 BC004132 AAH04132 BC013246 BM781594 D31890 BAA06688 D32053 BAA22084 DQ892301 ABM83227 DQ895500 ABM86426 NM_001130089 NP_001123561 NM_005548 NP_005539
|
| Function |
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation. {ECO:0000269|PubMed:15851690, ECO:0000269|PubMed:5338216}.
|
| Subcellular Location |
Isoform Cytoplasmic: Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Secreted. Note=Secretion is induced by TNF-alpha.
|
| Top Pathways |
Aminoacyl-tRNA biosynthesis
|