| Gene Symbol | U2AF2 |
|---|---|
| Entrez Gene | 11338 |
| Alt Symbol | U2AF65 |
| Species | Human |
| Gene Type | protein-coding |
| Description | U2 small nuclear RNA auxiliary factor 2 |
| Other Description | U2 (RNU2) small nuclear RNA auxiliary factor 2|U2 auxiliary factor 65 kDa subunit|U2 small nuclear ribonucleoprotein auxiliary factor (65kD)|U2 snRNP auxiliary factor large subunit|hU2AF65|splicing factor U2AF 65 kDa subunit |
| Swissprots | Q96HC5 P26368 |
| Accessions | EAW72402 EAW72403 EAW72404 P26368 AB451261 BAG70075 AB451387 BAG70201 AK311672 BC008740 AAH08740 BC030574 AAH30574 CN364862 DQ592840 JF432180 ADZ15397 X64044 CAA45409 XM_006722994 XP_006723057 XM_011526410 XP_011524712 NM_001012478 NP_001012496 NM_007279 NP_009210 |
| Function | Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:21536736}. |
| Subcellular Location | Nucleus. |
| Top Pathways | Spliceosome |
U2 small nuclear RNA auxiliary factor 2, ELISA Kit - MBS9322829 from MyBioSource
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Human U2AF2 ELISA Kit - E040196 from Biobool
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