U2AF2

Gene Symbol U2AF2
Entrez Gene 11338
Alt Symbol U2AF65
Species Human
Gene Type protein-coding
Description U2 small nuclear RNA auxiliary factor 2
Other Description U2 (RNU2) small nuclear RNA auxiliary factor 2|U2 auxiliary factor 65 kDa subunit|U2 small nuclear ribonucleoprotein auxiliary factor (65kD)|U2 snRNP auxiliary factor large subunit|hU2AF65|splicing factor U2AF 65 kDa subunit
Swissprots Q96HC5 P26368
Accessions EAW72402 EAW72403 EAW72404 P26368 AB451261 BAG70075 AB451387 BAG70201 AK311672 BC008740 AAH08740 BC030574 AAH30574 CN364862 DQ592840 JF432180 ADZ15397 X64044 CAA45409 XM_006722994 XP_006723057 XM_011526410 XP_011524712 NM_001012478 NP_001012496 NM_007279 NP_009210
Function Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:21536736}.
Subcellular Location Nucleus.
Top Pathways Spliceosome

U2AF2-Over-expression-Lysate - LY14743a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag U2AF2 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 62) or transiently transfected with theU2AF2 gene.

U2AF2 overexpression lysate - LY416055 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

U2AF2 Overexpression Lysate (Native) - NBP2-07511 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: U2AF2 Overexpression Lysate (Adult Normal) [NBP2-07511] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for U2AF2.

Panoply™ Human U2AF2 Knockdown Stable Cell Line - CSC-DC016924 from Creative biogene

Category Cell Line
Species Human
Search more