U2AF2

Gene Symbol U2AF2
Entrez Gene 11338
Alt Symbol U2AF65
Species Human
Gene Type protein-coding
Description U2 small nuclear RNA auxiliary factor 2
Other Description U2 (RNU2) small nuclear RNA auxiliary factor 2|U2 auxiliary factor 65 kDa subunit|U2 small nuclear ribonucleoprotein auxiliary factor (65kD)|U2 snRNP auxiliary factor large subunit|hU2AF65|splicing factor U2AF 65 kDa subunit
Swissprots Q96HC5 P26368
Accessions EAW72402 EAW72403 EAW72404 P26368 AB451261 BAG70075 AB451387 BAG70201 AK311672 BC008740 AAH08740 BC030574 AAH30574 CN364862 DQ592840 JF432180 ADZ15397 X64044 CAA45409 XM_006722994 XP_006723057 XM_011526410 XP_011524712 NM_001012478 NP_001012496 NM_007279 NP_009210
Function Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:19470458, ECO:0000269|PubMed:19574390, ECO:0000269|PubMed:21536736}.
Subcellular Location Nucleus.
Top Pathways Spliceosome

U2AF65 CRISPR/Cas9 KO Plasmid (h) - sc-402059 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 HDR Plasmid (h) - sc-402059-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 Double Nickase Plasmid (h) - sc-402059-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 Double Nickase Plasmid (h2) - sc-402059-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 CRISPR Activation Plasmid (h) - sc-402059-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 CRISPR Activation Plasmid (h2) - sc-402059-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 Lentiviral Activation Particles (h) - sc-402059-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 Lentiviral Activation Particles (h2) - sc-402059-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

U2AF65 siRNA (h) - sc-37667 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

U2AF65 shRNA Plasmid (h) - sc-37667-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

U2AF65 shRNA (h) Lentiviral Particles - sc-37667-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

U2AF2 RNAi - H00011338-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU044611 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22331 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22331 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

U2AF2 siRNA (Human) - CRH7765 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

U2AF2 RNAi - H00011338-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

U2AF2 - MBS8208004 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human U2AF2 (NM_007279.2) - SHH438576 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human U2AF2(NM_001012478.1) - SHL109362 from Creative biogene

Category siRNA
Species Reactivities Human

Human U2AF2 siRNA - orb268267 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

U2AF2 shRNA Plasmid (Human) - CHH7765 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

U2AF2 miRNA 3'UTR clone - MiUTR1H-10917 from Creative biogene

Species Reactivities Human

U2AF2 miRNA 3'UTR clone - MiUTR1H-10918 from Creative biogene

Species Reactivities Human
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