THAP1

Gene Symbol THAP1
Entrez Gene 55145
Alt Symbol DYT6
Species Human
Gene Type protein-coding
Description THAP domain containing, apoptosis associated protein 1
Other Description 4833431A01Rik|THAP domain protein 1|THAP domain-containing protein 1|nuclear proapoptotic factor
Swissprots H9KV49 Q6IA99 Q53FQ1 D3DSY5 A6NCB6 Q9NVV9
Accessions EAW63205 EAW63206 Q9NVV9 AI475984 AK001339 BAA91635 AK223231 BAD96951 AL832077 BC021721 AAH21721 BG497522 CD639319 CD709111 CR457256 CAG33537 JF432589 ADZ15806 NM_018105 NP_060575 NM_199003 NP_945354
Function DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.
Subcellular Location Nucleus, nucleoplasm {ECO:0000269|PubMed:12717420}. Nucleus, PML body {ECO:0000269|PubMed:12717420}.
Tissue Specificity Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. {ECO:0000269|PubMed:20200153}.

THAP1 (D-13) - sc-98175 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

THAP1 (C-18) - sc-98174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

THAP1 (3H3) - sc-135578 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
THAP1 (3H3): sc-135578. Western blot analysis of THAP1 expression in human THAP1 transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-THAP1 antibody - ab118368 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-THAP1 antibody (ab118368) at 1/1000 dilution + Jurkat cell lystate at 50 µg

Anti-THAP1 antibody - ab172794 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-THAP1 antibody (ab172794) at 1 µg/mlLane 1 : THAP1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-THAP1 antibody - ab57481 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57481 THAP1 antibody at 1ug/ml.

THAP1 Antibody - H00055145-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: THAP1 Antibody [H00055145-D01P] - Analysis of THAP1 expression in Jurkat.

THAP1 Antibody (2C1-2F2) - H00055145-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C1-2F2
Western Blot: THAP1 Antibody (2C1-2F2) [H00055145-M01] - Analysis of THAP1 over-expressed 293 cell line, cotransfected with THAP1 Validated Chimera RNAi ( Cat # H00055145-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with THAP1 monoclonal antibody (M01), clone 2C1-2F2 (Cat # H00055145-M01 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.

THAP1 Antibody - H00055145-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: THAP1 Antibody [H00055145-B01P] - Analysis of THAP1 expression in transfected 293T cell line by THAP1 polyclonal antibody. Lane 1: THAP1 transfected lysate(23.43 KDa). Lane 2: Non-transfected lysate.

THAP1 Antibody - H00055145-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

THAP1 Polyclonal Antibody - bs-7103R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Monoclonal Anti-THAP1 antibody produced in mouse - WH0055145M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C1-2F2
<B>Immunoblotting</B><BR/>Monoclonal Anti-THAP1, <B>Cat. No. WH0055145M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~49.54 kDa using immunogen protein lysate.

Anti-THAP1 antibody produced in rabbit - SAB1411032 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-THAP1: <B>Cat. No. SAB1411032</B>: Antibody concentration: 1-5 μg/mL. Specific band of ~24.9 kDa using Jurkat lysate.

Anti-THAP1 (181-195) antibody produced in rabbit - SAB1105261 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-THAP1 antibody produced in mouse - SAB1407621 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-THAP1: <B>Cat. No. SAB1407621</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~23.4 kDa using THAP1 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

THAP1-Antibody-monoclonal-M01 - AT4231a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C1-2F2
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (49.17 KDa) .

THAP1 Polyclonal Antibody - A7472 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using THAP1 antibody.

THAP1 antibody - 70R-20803 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

THAP1 antibody - 12584-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
293 cell were subjected to SDS PAGE followed by western blot with 12584-1-AP(THAP1 Antibody) at dilution of 1:800

THAP1 antibody - H00055145-B01P from Acris Antibodies

Prices $360.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot analysis of THAP1 expression in transfected 293T cell line (H00055145-T01) by THAP1 MaxPab polyclonal antibody. Lane 1: THAP1 transfected lysate(23.43 KDa). Lane 2: Non-transfected lysate.

THAP1 antibody - H00055145-D01 from Acris Antibodies

Prices $390.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
THAP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of THAP1 expression in Jurkat.

THAP1 antibody - H00055145-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot analysis of THAP1 expression in transfected 293T cell line (H00055145-T02) by THAP1 MaxPab polyclonal antibody. Lane 1: THAP1 transfected lysate(24.90 KDa). Lane 2: Non-transfected lysate.

THAP1 antibody - H00055145-M01 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2C1-2F2
Western Blot analysis of THAP1 expression in transfected 293T cell line by THAP1 monoclonal antibody (M01), clone 2C1-2F2.Lane 1: THAP1 transfected lysate(24.9 KDa).Lane 2: Non-transfected lysate.

Anti-THAP1 antibody - STJ29608 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

THAP1 antibody - 12584-1-AP from Proteintech Group

Prices $279.00
Sizes con: 75 μg/150μl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human colon cancer using 12584-1-AP(THAP1 antibody) at dilution of 1:50 (under 40x lens)
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