| Gene Symbol |
THAP1
|
| Entrez Gene |
55145
|
| Alt Symbol |
DYT6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
THAP domain containing, apoptosis associated protein 1
|
| Other Description |
4833431A01Rik|THAP domain protein 1|THAP domain-containing protein 1|nuclear proapoptotic factor
|
| Swissprots |
H9KV49 Q6IA99 Q53FQ1 D3DSY5 A6NCB6 Q9NVV9
|
| Accessions |
EAW63205 EAW63206 Q9NVV9 AI475984 AK001339 BAA91635 AK223231 BAD96951 AL832077 BC021721 AAH21721 BG497522 CD639319 CD709111 CR457256 CAG33537 JF432589 ADZ15806 NM_018105 NP_060575 NM_199003 NP_945354
|
| Function |
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.
|
| Subcellular Location |
Nucleus, nucleoplasm {ECO:0000269|PubMed:12717420}. Nucleus, PML body {ECO:0000269|PubMed:12717420}.
|
| Tissue Specificity |
Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. {ECO:0000269|PubMed:20200153}.
|