THAP1

Gene Symbol	THAP1
Entrez Gene	55145
Alt Symbol	DYT6
Species	Human
Gene Type	protein-coding
Description	THAP domain containing, apoptosis associated protein 1
Other Description	4833431A01Rik|THAP domain protein 1|THAP domain-containing protein 1|nuclear proapoptotic factor
Swissprots	H9KV49 Q6IA99 Q53FQ1 D3DSY5 A6NCB6 Q9NVV9
Accessions	EAW63205 EAW63206 Q9NVV9 AI475984 AK001339 BAA91635 AK223231 BAD96951 AL832077 BC021721 AAH21721 BG497522 CD639319 CD709111 CR457256 CAG33537 JF432589 ADZ15806 NM_018105 NP_060575 NM_199003 NP_945354
Function	DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:12717420}. Nucleus, PML body {ECO:0000269|PubMed:12717420}.
Tissue Specificity	Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. {ECO:0000269|PubMed:20200153}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

THAP1-Over-expression-Lysate - LY14387a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

THAP1 293T Cell Transient Overexpression Lysate(Denatured) - H00055145-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

THAP1 overexpression lysate - LY404715 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

THAP1 overexpression lysate - LY413231 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

THAP1 overexpression lysate - LY430784 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

THAP1 293 Cell Lysate - 406405 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

THAP1 Overexpression Lysate (Denatured) - H00055145-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

THAP1 Overexpression Lysate (Native) - NBL1-16871 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

THAP1 Over-expression Lysate Product - GWB-64370F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

THAP1 Overexpression Lysate (Native) - NBP2-04662 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

THAP1 Overexpression Lysate (Native) - NBP2-10089 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

THAP1 Overexpression Lysate (Denatured) - H00055145-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human THAP1 Knockdown Stable Cell Line - CSC-DC015887 from Creative biogene Category Cell Line Species Human

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