THAP1

Gene Symbol	THAP1
Entrez Gene	55145
Alt Symbol	DYT6
Species	Human
Gene Type	protein-coding
Description	THAP domain containing, apoptosis associated protein 1
Other Description	4833431A01Rik|THAP domain protein 1|THAP domain-containing protein 1|nuclear proapoptotic factor
Swissprots	H9KV49 Q6IA99 Q53FQ1 D3DSY5 A6NCB6 Q9NVV9
Accessions	EAW63205 EAW63206 Q9NVV9 AI475984 AK001339 BAA91635 AK223231 BAD96951 AL832077 BC021721 AAH21721 BG497522 CD639319 CD709111 CR457256 CAG33537 JF432589 ADZ15806 NM_018105 NP_060575 NM_199003 NP_945354
Function	DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. {ECO:0000269|PubMed:12717420, ECO:0000269|PubMed:17003378, ECO:0000269|PubMed:20200153}.
Subcellular Location	Nucleus, nucleoplasm {ECO:0000269|PubMed:12717420}. Nucleus, PML body {ECO:0000269|PubMed:12717420}.
Tissue Specificity	Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. {ECO:0000269|PubMed:20200153}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

THAP1 CRISPR/Cas9 KO Plasmid (h) - sc-405020 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 HDR Plasmid (h) - sc-405020-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 Double Nickase Plasmid (h) - sc-405020-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 Double Nickase Plasmid (h2) - sc-405020-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 CRISPR Activation Plasmid (h) - sc-405020-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 CRISPR Activation Plasmid (h2) - sc-405020-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 Lentiviral Activation Particles (h) - sc-405020-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 Lentiviral Activation Particles (h2) - sc-405020-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

THAP1 siRNA (h) - sc-77834 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

THAP1 shRNA Plasmid (h) - sc-77834-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

THAP1 shRNA (h) Lentiviral Particles - sc-77834-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

THAP1 RNAi - H00055145-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

THAP1 RNAi - H00055145-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

THAP1 RNAi - H00055145-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU069391 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21291 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21291 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

THAP1 siRNA (Human) - CRJ0502 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

THAP1 - MBS8217660 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human THAP1 (NM_199003.1) - SHH426676 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human THAP1(NM_018105.2) - SHL042418 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human THAP1(NM_199003.1) - SHL042436 from Creative biogene Category siRNA Species Reactivities Human

Human THAP1 siRNA - orb271003 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

THAP1 shRNA Plasmid (Human) - CHJ0502 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

THAP1 miRNA 3'UTR clone - MiUTR1H-10370 from Creative biogene Species Reactivities Human

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