SLC22A2

Gene Symbol SLC22A2
Entrez Gene 6582
Alt Symbol OCT2
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation transporter), member 2
Other Description organic cation transporter 2|solute carrier family 22 member 2
Swissprots Q6PIQ8 Q9NQB9 Q5T7Q6 O15244 Q8NG62
Accessions CAB96133 EAW47601 EAW47602 O15244 AB075951 BAC02720 AK290787 BAF83476 BC030978 AAH30978 BC039899 AAH39899 X98333 CAA66978 NM_003058 NP_003049 NM_153191
Function Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15496291, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:16006492, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16314463, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576}.
Top Pathways Choline metabolism in cancer

SLC22A2 overexpression lysate - LY418928 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SLC22A2 293 Cell Lysate - 408848 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

SLC22A2/OCT2 Overexpression Lysate (Native) - NBL1-16035 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SLC22A2 Overexpression Lysate (Adult Normal) [NBL1-16035] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SLC22A2.

SLC22A2 Over-expression Lysate Product - GWB-F2CAD6 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human SLC22A2 Knockdown Stable Cell Line - CSC-DC014384 from Creative biogene

Category Cell Line
Species Human
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