SLC22A2

Gene Symbol SLC22A2
Entrez Gene 6582
Alt Symbol OCT2
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation transporter), member 2
Other Description organic cation transporter 2|solute carrier family 22 member 2
Swissprots Q6PIQ8 Q9NQB9 Q5T7Q6 O15244 Q8NG62
Accessions CAB96133 EAW47601 EAW47602 O15244 AB075951 BAC02720 AK290787 BAF83476 BC030978 AAH30978 BC039899 AAH39899 X98333 CAA66978 NM_003058 NP_003049 NM_153191
Function Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15496291, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:16006492, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16314463, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576}.
Top Pathways Choline metabolism in cancer

Human SLC22A2/OCT2 (AAH39899) VersaClone cDNA - RDC0446 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Human

Rat SLC22A2/OCT2 (CAB52215) VersaClone cDNA - RDC0999 from R&D Systems

Prices $199.00
Sizes 10 µg
Species Rat

SLC22A2 - MBS1278292 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC030978

human SLC22A2 ORF clone - CDCH081254 from Creative Biomart

Species Human
Accession NM_003058

human SLC22A2 ORF clone - CDCH081255 from Creative Biomart

Species Human
Accession NM_003058

Human SLC22A2 ORF Clone(NM_003058.3) - CDCL175729 from Creative Biomart

Species Human
Accession NM_003058.3

Human SLC22A2 ORF Clone (BC030978) - CDCS411123 from Creative biogene

Species Human
Accession O15244
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