SLC22A2

Gene Symbol SLC22A2
Entrez Gene 6582
Alt Symbol OCT2
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic cation transporter), member 2
Other Description organic cation transporter 2|solute carrier family 22 member 2
Swissprots Q6PIQ8 Q9NQB9 Q5T7Q6 O15244 Q8NG62
Accessions CAB96133 EAW47601 EAW47602 O15244 AB075951 BAC02720 AK290787 BAF83476 BC030978 AAH30978 BC039899 AAH39899 X98333 CAA66978 NM_003058 NP_003049 NM_153191
Function Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15496291, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:16006492, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16314463, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576}.
Top Pathways Choline metabolism in cancer

OCT2 CRISPR/Cas9 KO Plasmid (h) - sc-402053 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 HDR Plasmid (h) - sc-402053-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 Double Nickase Plasmid (h) - sc-402053-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 Double Nickase Plasmid (h2) - sc-402053-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 CRISPR Activation Plasmid (h) - sc-402053-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 CRISPR Activation Plasmid (h2) - sc-402053-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 Lentiviral Activation Particles (h) - sc-402053-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 Lentiviral Activation Particles (h2) - sc-402053-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OCT2 siRNA (h) - sc-42554 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCT2 shRNA Plasmid (h) - sc-42554-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OCT2 shRNA (h) Lentiviral Particles - sc-42554-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC22A2/OCT2 RNAi - H00006582-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU017241 from Sigma-Aldrich

Category siRNA

SLC22A2 siRNA (Human) - CRH4470 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A2/OCT2 RNAi - H00006582-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SLC22A2 - MBS8236850 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC22A2 (NM_003058.3) - SHH409116 from Creative biogene

Category siRNA
Species Reactivities Human

Human SLC22A2 siRNA - orb264972 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A2 shRNA Plasmid (Human) - CHH4470 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC22A2 miRNA 3'UTR clone - MiUTR4H-TG08180 from Creative biogene

Species Reactivities Human
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