SLC22A2

Gene Symbol	SLC22A2
Entrez Gene	6582
Alt Symbol	OCT2
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic cation transporter), member 2
Other Description	organic cation transporter 2|solute carrier family 22 member 2
Swissprots	Q6PIQ8 Q9NQB9 Q5T7Q6 O15244 Q8NG62
Accessions	CAB96133 EAW47601 EAW47602 O15244 AB075951 BAC02720 AK290787 BAF83476 BC030978 AAH30978 BC039899 AAH39899 X98333 CAA66978 NM_003058 NP_003049 NM_153191
Function	Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15496291, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:16006492, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16314463, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576}.
Top Pathways	Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

OCT2 (C-13) - sc-19814 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

OCT2 (H-62) - sc-292622 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

OCT2 (X-22) - sc-133867 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-SLC22A2 antibody - ab198800 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 antibody - ab58182 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SLC22A2 antibody [EPR11248] - ab170871 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11248

Anti-SLC22A2 antibody - C-terminal - ab138753 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (C-Terminus) - LS-C37852 from LifeSpan Bioscience Prices $385.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (clone 11n175, Azide-free) - LS-C184893 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 11n175

Anti-SLC22A2 Antibody (aa513-541, APC) - LS-C217557 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (aa513-541, AP) - LS-C217556 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (aa513-541, FITC) - LS-C217559 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (aa513-541, Biotin) - LS-C217558 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (aa513-541, Azide-free, HRP) - LS-C217560 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (aa513-541, PE) - LS-C217561 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody - LS-C314092 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A2 / OCT2 Antibody (aa261-370, Azide-free) - LS-C328727 from LifeSpan Bioscience Host Mouse Clonality Monoclonal

Anti-SLC22A2 Antibody (aa513-541) - LS-C330146 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (N-Terminus) - LS-C80615 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC22A2 Antibody (aa514-541) - LS-C158989 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

SLC22A2/OCT2 Antibody - NBP1-89417 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SLC22A2/OCT2 Antibody (640438) - MAB6547 from Novus Biologicals Prices $99.00, $249.00 Sizes 25 µg, 100 µg Host Mouse Clonality Monoclonal Clone 640438

OCT2 Antibody - NB100-91900 from Novus Biologicals Prices $349.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

SLC22A2/OCT2 Antibody - NBP1-59451 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

OCT2 Antibody (9A2) - NBP2-00351 from Novus Biologicals Prices $329.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone 9A2

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