SLC22A2

Gene Symbol	SLC22A2
Entrez Gene	6582
Alt Symbol	OCT2
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic cation transporter), member 2
Other Description	organic cation transporter 2|solute carrier family 22 member 2
Swissprots	Q6PIQ8 Q9NQB9 Q5T7Q6 O15244 Q8NG62
Accessions	CAB96133 EAW47601 EAW47602 O15244 AB075951 BAC02720 AK290787 BAF83476 BC030978 AAH30978 BC039899 AAH39899 X98333 CAA66978 NM_003058 NP_003049 NM_153191
Function	Mediates tubular uptake of organic compounds from circulation. Mediates the influx of agmatine, dopamine, noradrenaline (norepinephrine), serotonin, choline, famotidine, ranitidine, histamin, creatinine, amantadine, memantine, acriflavine, 4-[4-(dimethylamino)-styryl]-N-methylpyridinium ASP, amiloride, metformin, N-1-methylnicotinamide (NMN), tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, cisplatin and oxaliplatin. Cisplatin may develop a nephrotoxic action. Transport of creatinine is inhibited by fluoroquinolones such as DX-619 and LVFX. This transporter is a major determinant of the anticancer activity of oxaliplatin and may contribute to antitumor specificity. {ECO:0000269|PubMed:12089365, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15496291, ECO:0000269|PubMed:15783073, ECO:0000269|PubMed:16006492, ECO:0000269|PubMed:16272756, ECO:0000269|PubMed:16314463, ECO:0000269|PubMed:16394027, ECO:0000269|PubMed:16914559, ECO:0000269|PubMed:16951202, ECO:0000269
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Mainly expressed in kidney. Localized at the luminal membrane and basolateral membrane of kidney distal tubule and proximal tubules. To a lower extent, expressed in neurons of the cerebral cortex and in various subcortical nuclei (at protein levels). Also detected in secretory phase endometrium; in scattered cells in the stroma. {ECO:0000269|PubMed:11912245, ECO:0000269|PubMed:17393420, ECO:0000269|PubMed:9260930, ECO:0000269|PubMed:9687576}.
Top Pathways	Choline metabolism in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC22A2 full length protein - ab159537 from Abcam Category Protein Source Wheat germ Species Human

Human SLC22A2 protein fragment - ab159538 from Abcam Category Protein Source Wheat germ Species Human

SLC22A2 Antibody Blocking Peptide - LS-E6189 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SLC22A2/OCT2 Protein - H00006582-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human SLC22A2/OCT2 Protein - H00006582-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

SLC22A2-Antibody-C-term-Blocking-Peptide - BP18829b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

OCT2 peptide - orb72254 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg Source This polypeptide is homologous to the Rat, Mouse protein.

SLC22A2 peptide - orb217945 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SLC22A2 Blocking Peptide - 33R-6311 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

OCT2 Blocking Peptide - abx063276 from Abbexa Category Peptide Species Human, Mouse, Rat

OCT2 Blocking Peptide - abx063107 from Abbexa Category Peptide Species Human, Mouse, Rat, Dog, Pig

SLC22A2 / OCT2 - H00006582-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

SLC22A2 fusion protein - ag4968 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

SLC22A2 fusion protein - ag4500 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

OCT2 Blocking Peptide - CBP2082 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

SLC22A2 Peptide - BS60420P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

SLC22A2 Protein - abx163589 from Abbexa Category Protein Species Human, Rat

SLC22A2/OCT2 Protein - NBP1-89417PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

SLC22A2-Blocking-Peptide-N-term - BP21683a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SLC22A2 Peptide, Human - M34GP14384H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLC22A2/OCT2 Recombinant Protein Antigen - NBP2-52942PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E. coli Species Human

Solute carrier family 22 member 2 (SLC22A2), Recombinant Protein - MBS1165458 from MyBioSource Category Protein Prices $1,375.00, $1,835.00 Sizes 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Solute carrier family 22 member 2 (SLC22A2), Recombinant Protein - MBS7085567 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Orangutan

SLC22A2/OCT2 Recombinant Protein Antigen - NBP2-52941PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Source E. coli Species Human

Recombinant Human SLC22A2 Protein, GST-tagged - SLC22A2-670H from Creative Biomart Category Protein Source Wheat Germ Species Human

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