| Gene Symbol |
GNL3
|
| Entrez Gene |
26354
|
| Alt Symbol |
C77032, E2IG3, NNP47, NS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide binding protein-like 3 (nucleolar)
|
| Other Description |
E2-induced gene 3 protein|estradiol-induced nucleotide binding protein|guanine nucleotide-binding protein-like 3|novel nucleolar protein 47|nucleolar GTP-binding protein 3|nucleostemin
|
| Swissprots |
Q96SV7 B2RDC1 Q9UJY0 Q96SV6 Q5PU80 Q9BVP2
|
| Accessions |
EAW65249 EAW65250 EAW65251 EAW65252 Q9BVP2 AF191018 AAF09482 AI028402 AK027514 BAB55168 AK027516 BAB55169 AK315484 BAG37868 AY825265 AAV74413 BC001024 AAH01024 BF732788 CF272475 EU831969 ACE87410 EU832062 ACE86724 NM_014366 NP_055181 NM_206825 NP_996561 NM_206826 NP_996562
|
| Function |
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250}.
|
| Tissue Specificity |
Increased levels in lung tissue in cancer patients. {ECO:0000269|PubMed:16012751}.
|
| Top Pathways |
Ribosome biogenesis in eukaryotes
|