Gene Symbol | GNL3 |
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Entrez Gene | 26354 |
Alt Symbol | C77032, E2IG3, NNP47, NS |
Species | Human |
Gene Type | protein-coding |
Description | guanine nucleotide binding protein-like 3 (nucleolar) |
Other Description | E2-induced gene 3 protein|estradiol-induced nucleotide binding protein|guanine nucleotide-binding protein-like 3|novel nucleolar protein 47|nucleolar GTP-binding protein 3|nucleostemin |
Swissprots | Q96SV7 B2RDC1 Q9UJY0 Q96SV6 Q5PU80 Q9BVP2 |
Accessions | EAW65249 EAW65250 EAW65251 EAW65252 Q9BVP2 AF191018 AAF09482 AI028402 AK027514 BAB55168 AK027516 BAB55169 AK315484 BAG37868 AY825265 AAV74413 BC001024 AAH01024 BF732788 CF272475 EU831969 ACE87410 EU832062 ACE86724 NM_014366 NP_055181 NM_206825 NP_996561 NM_206826 NP_996562 |
Function | May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Shuttles between the nucleus and nucleolus. {ECO:0000250}. |
Tissue Specificity | Increased levels in lung tissue in cancer patients. {ECO:0000269|PubMed:16012751}. |
Top Pathways | Ribosome biogenesis in eukaryotes |
Human Nucleostemin full length protein - ab132134 from Abcam
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Human Nucleostemin full length protein - ab161973 from Abcam
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Human Nucleostemin protein fragment - ab161976 from Abcam
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Mouse Nucleostemin peptide - ab33354 from Abcam
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GNL3 / NS / Nucleostemin Antibody Blocking Peptide - LS-E2935 from LifeSpan Bioscience
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GNL3 / NS / Nucleostemin Antibody Blocking Peptide - LS-E2936 from LifeSpan Bioscience
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GNL3 / NS / Nucleostemin Antibody Blocking Peptide - LS-E6759 from LifeSpan Bioscience
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GNL3 / NS / Nucleostemin Antibody Blocking Peptide - LS-E21527 from LifeSpan Bioscience
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GNL3 / NS / Nucleostemin Antibody Blocking Peptide - LS-E21528 from LifeSpan Bioscience
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Recombinant Human Nucleostemin Protein - H00026354-P01 from Novus Biologicals
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Recombinant Human Nucleostemin Protein - H00026354-Q01 from Novus Biologicals
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Nucleostemin Peptide - P0364 from Novus Biologicals
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Nucleostemin Peptide - P0363 from Novus Biologicals
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Nucleostemin-GNL3-Antibody-Center-Blocking-peptide - BP1405c from Abgent, a WuXi AppTec company
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Nucleostemin-GNL3-Antibody-C-term-Blocking-peptide - BP1405b from Abgent, a WuXi AppTec company
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GNL3 Blocking Peptide - 33R-8008 from Fitzgerald
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GNL3 Blocking Peptide - 33R-6534 from Fitzgerald
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Nucleostemin - H00026354-P01-10 from Acris Antibodies
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Nucleostemin - H00026354-P01-25 from Acris Antibodies
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Nucleostemin - H00026354-Q01-10 from Acris Antibodies
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Nucleostemin - H00026354-Q01-25 from Acris Antibodies
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GNL3 fusion protein - Ag7056 from Proteintech Group
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Recombinant Human GNL3, His-tagged - GNL3-13370H from Creative Biomart
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Recombinant Human Guanine nucleotide-binding protein-like 3(GNL3) - CSB-YP874819HU CSB-EP874819HU CSB-BP874819HU CSB-MP874819HU from Cusabio
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Nucleostemin (full length, N-term HIS tag, transcript variant 1) - TP760526 from Acris Antibodies
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