UNC5C

Gene Symbol UNC5C
Entrez Gene 8633
Alt Symbol UNC5H3
Species Human
Gene Type protein-coding
Description unc-5 homolog C (C. elegans)
Other Description netrin receptor UNC5C|protein unc-5 homolog 3|protein unc-5 homolog C|unc-5 homolog 3|unc5 (C.elegans homolog) c
Swissprots Q8IUT0 O95185
Accessions AAY41022 EAX06061 EAX06062 O95185 AF055634 AAC67491 AK022487 AK290500 BAF83189 AK308421 BC034747 BC041156 AAH41156 BX538341 XM_005263321 XP_005263378 NM_003728 NP_003719
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. {ECO:0000269|PubMed:9782087}.
Top Pathways Axon guidance

UNC5H3 (H-70) - sc-135077 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

UNC5H3 (K-18) - sc-54442 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UNC5H3 (K-18): sc-54442. Western blot analysis of UNC5H3 expression in K-562 (A), Jurkat (B), COLO205 (C) and HeLa (D) whole cell lysates.

UNC5H3 (Zg06) - sc-80422 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

UNC5H3 (E-16) - sc-54441 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-UNC5C antibody - ab91408 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab91408 stained SKNSH cells. The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab91408 at 1/50 dilution overnight at +4°C. The secondary antibody (pseudo-colored green) was Alexa Fluor® 488 goat anti- rabbit (ab150081) IgG (H+L) preadsorbed, used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1h at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-UNC5C antibody [MM0595-7F31] - ab89938 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0595-7F31
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4µm) labelling UNC5C with ab89938. Tissue was treated with 15µg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

Anti-UNC5C antibody - N-terminal - ab156154 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-UNC5C antibody - N-terminal (ab156154) at 1/100 dilution + CEM cell line lysate at 35 µg

Anti-UNC5H3 / UNC5C Antibody (aa88-117, AP) - LS-C273052 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa88-117, APC) - LS-C273053 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa88-117, Biotin) - LS-C273054 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa88-117, FITC) - LS-C273055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (C-Terminus) - LS-C80729 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-UNC5H3 / UNC5C Antibody (aa121-170) - LS-C187315 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human 293T . UNC5C antibody dilution 1.0 ug/ml.

Anti-UNC5H3 / UNC5C Antibody (aa88-117, Azide-free, HRP) - LS-C273056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa395-444) - LS-C116305 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UNC5C antibody LS-C116305 Western blot of COLO205 cell lysate.

Anti-UNC5H3 / UNC5C Antibody (aa188-217, Biotin) - LS-C283954 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa88-117, PE) - LS-C273058 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa188-217, AP) - LS-C283955 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa470-519) - LS-C201492 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HepG2. UNC5C antibody dilution 1.0 ug/ml.

Anti-UNC5H3 / UNC5C Antibody (aa188-217, APC) - LS-C283956 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa188-217, FITC) - LS-C283957 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa88-117) - LS-C157024 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
UNC5C Antibody western blot of CEM cell line lysates (35 ug/lane). The UNC5C antibody detected the UNC5C protein (arrow).

Anti-UNC5H3 / UNC5C Antibody (aa188-217, Azide-free, HRP) - LS-C283958 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa188-217, PE) - LS-C283959 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UNC5H3 / UNC5C Antibody (aa88-117) - LS-C326199 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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