| Gene Symbol |
UNC5C
|
| Entrez Gene |
8633
|
| Alt Symbol |
UNC5H3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
unc-5 homolog C (C. elegans)
|
| Other Description |
netrin receptor UNC5C|protein unc-5 homolog 3|protein unc-5 homolog C|unc-5 homolog 3|unc5 (C.elegans homolog) c
|
| Swissprots |
Q8IUT0 O95185
|
| Accessions |
AAY41022 EAX06061 EAX06062 O95185 AF055634 AAC67491 AK022487 AK290500 BAF83189 AK308421 BC034747 BC041156 AAH41156 BX538341 XM_005263321 XP_005263378 NM_003728 NP_003719
|
| Function |
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. {ECO:0000269|PubMed:9782087}.
|
| Top Pathways |
Axon guidance
|