UNC5C

Gene Symbol UNC5C
Entrez Gene 8633
Alt Symbol UNC5H3
Species Human
Gene Type protein-coding
Description unc-5 homolog C (C. elegans)
Other Description netrin receptor UNC5C|protein unc-5 homolog 3|protein unc-5 homolog C|unc-5 homolog 3|unc5 (C.elegans homolog) c
Swissprots Q8IUT0 O95185
Accessions AAY41022 EAX06061 EAX06062 O95185 AF055634 AAC67491 AK022487 AK290500 BAF83189 AK308421 BC034747 BC041156 AAH41156 BX538341 XM_005263321 XP_005263378 NM_003728 NP_003719
Function Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}.
Subcellular Location Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. {ECO:0000269|PubMed:9782087}.
Top Pathways Axon guidance

UNC5H3 CRISPR/Cas9 KO Plasmid (h) - sc-403782 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 HDR Plasmid (h) - sc-403782-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 Double Nickase Plasmid (h) - sc-403782-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 Double Nickase Plasmid (h2) - sc-403782-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 CRISPR Activation Plasmid (h) - sc-403782-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 CRISPR Activation Plasmid (h2) - sc-403782-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 Lentiviral Activation Particles (h) - sc-403782-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 Lentiviral Activation Particles (h2) - sc-403782-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

UNC5H3 siRNA (h) - sc-72284 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC5H3 shRNA Plasmid (h) - sc-72284-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

UNC5H3 shRNA (h) Lentiviral Particles - sc-72284-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU051711 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22502 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22502 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UNC5C siRNA (Human) - CRH5672 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC5H3/UNC5C RNAi - H00008633-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

UNC5C - MBS8226981 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human UNC5C siRNA - orb266174 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UNC5C shRNA Plasmid (Human) - CHH5672 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UNC5C miRNA 3'UTR clone - MiUTR3H-06117 from Creative biogene

Species Reactivities Human
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