Gene Symbol | UNC5C |
---|---|
Entrez Gene | 8633 |
Alt Symbol | UNC5H3 |
Species | Human |
Gene Type | protein-coding |
Description | unc-5 homolog C (C. elegans) |
Other Description | netrin receptor UNC5C|protein unc-5 homolog 3|protein unc-5 homolog C|unc-5 homolog 3|unc5 (C.elegans homolog) c |
Swissprots | Q8IUT0 O95185 |
Accessions | AAY41022 EAX06061 EAX06062 O95185 AF055634 AAC67491 AK022487 AK290500 BAF83189 AK308421 BC034747 BC041156 AAH41156 BX538341 XM_005263321 XP_005263378 NM_003728 NP_003719 |
Function | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Mainly expressed in brain. Also expressed in kidney. Not expressed in developing or adult lung. {ECO:0000269|PubMed:9782087}. |
Top Pathways | Axon guidance |
Human UNC5H3 / UNC5C ELISA Kit (Sandwich ELISA) - LS-F12907 from LifeSpan Bioscience
|
||||||||||
Netrin receptor UNC5C, UNC5C, Human, ELISA Kit - E7813h from ARP American Research Products
|
||||||||||
Rat UNC5H3 / UNC5C ELISA Kit (Custom ELISA) - LS-F20133 from LifeSpan Bioscience
|
||||||||||
Chicken UNC5H3 / UNC5C ELISA Kit (Custom ELISA) - LS-F20132 from LifeSpan Bioscience
|
||||||||||
Mouse UNC5H3 / UNC5C ELISA Kit (Custom ELISA) - LS-F20134 from LifeSpan Bioscience
|
||||||||||
Human Netrin receptor UNC5C ELISA Kit - abx251732 from Abbexa
|
||||||||||
Human Human Netrin receptor UNC5C ELISA Kit - EKE55425 from Biomatik
|
||||||||||
UNC5C - EKH4746 from Nordic BioSite
|
||||||||||
UNC5C ELISA Kit (Human) (OKEH01829) - OKEH01829 from Aviva Systems Biology
|
||||||||||
Custom Human UNC5H3 ELISA - ELH-UNC5H3-1 from RayBiotech
|
||||||||||
Human UNC5C ELISA Kit - E026015 from Biobool
|
||||||||||
Human Netrin receptor UNC5C ELISA Kit - EK4779 from Signalway Antibody
|
||||||||||
anti-UNC5C antibody - ARG64871 from Arigo Biolaboratories
|
||||||||||
Netrin receptor UNC5C, ELISA Kit - MBS2885942 from MyBioSource
|
||||||||||
Netrin receptor UNC5C, ELISA Kit - MBS9428605 from MyBioSource
|
||||||||||
Human UNC5H3 / UNC5C ELISA Kit (Sandwich ELISA) - LS-F33754 from LifeSpan Bioscience
|