GPNMB

Gene Symbol	GPNMB
Entrez Gene	10457
Alt Symbol	HGFIN, NMB
Species	Human
Gene Type	protein-coding
Description	glycoprotein (transmembrane) nmb
Other Description	glycoprotein NMB|glycoprotein nmb-like protein|osteoactivin|transmembrane glycoprotein HGFIN|transmembrane glycoprotein NMB
Swissprots	A4D155 Q6UVX1 Q8N1A1 Q14956
Accessions	AAN59897 AAP22336 AAP22337 EAL24259 EAW93781 EAW93782 EAW93783 EAW93784 Q14956 AF322909 AAG42839 AI952217 AJ505015 CAD43718 AK292078 BAF84767 AK296779 BAG59357 AK297031 BAG59559 AK297051 BAG59577 AK297055 BAG59580 AK297803 BAG60141 AK303071 BAG64187 AK304671 BAG65446 AK312279 BAG35208 AY359124 AAQ89481 BC011595 AAH11595 BC025297 BC032783 AAH32783 BM750843 BT007074 AAP35737 BU537639 CD105306 DQ892084 ABM83010 DQ895277 ABM86203 X76534 CAA54044 XM_005249578 XP_005249635 NM_001005340 NP_001005340 NM_002510 NP_002501
Function	Could be a melanogenic enzyme. {ECO:0000250}.
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines.
Tissue Specificity	Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain. {ECO:0000269|PubMed:16489096, ECO:0000269|PubMed:16609006, ECO:0000269|PubMed:7814155}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GPNMB full length protein - ab153081 from Abcam Category Protein Source Wheat germ Species Human

Human GPNMB protein fragment - ab151652 from Abcam Category Protein Source HEK 293 cells Species Human

Human GPNMB protein fragment - ab153082 from Abcam Category Protein Source Wheat germ Species Human

Human GPNMB protein fragment - ab171588 from Abcam Category Protein Source E. coli Species Human

GPNMB / Osteoactivin Antibody Blocking Peptide - LS-E4852 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPNMB / Osteoactivin Antibody Blocking Peptide - LS-E16346 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GPNMB / Osteoactivin Antibody Blocking Peptide - LS-E16345 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NMB / Neuromedin B Antibody Blocking Peptide - LS-E7828 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Neuromedin B Recombinant Protein - H00004828-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 2 µg Species Human

Osteoactivin/GPNMB Partial Recombinant Protein - H00010457-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Osteoactivin/GPNMB Protein - NBP2-23082 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human Neuromedin B Protein - NBP2-23280 from Novus Biologicals Category Protein Prices $269.00 Sizes 50 µg Source E.coli Species Human

GPNMB-Antibody-C-term-Blocking-Peptide - BP17232b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Osteoactivin/GPNMB Fc Chimera, CF - 2550-AC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse Osteoactivin/GPNMB Fc Chimera, CF - 2330-AC-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human GPNMB protein - orb191259 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human GPNMB protein - orb191254 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human GPNMB protein - orb245277 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human NMB protein - orb191229 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Source E. coli Species Human

Human NMB protein - orb84462 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Species Human

Human NMB protein - orb138948 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

GPNMB protein (His tag) - 80R-2986 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

GPNMB / HGFIN (22-474, His-tag) - AR51104PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

GPNMB / HGFIN (22-474, His-tag) - AR51104PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

GPNMB / HGFIN - H00010457-P01-02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Source in vitro transl. Species Human

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