GPNMB
| Gene Symbol | GPNMB |
|---|---|
| Entrez Gene | 10457 |
| Alt Symbol | HGFIN, NMB |
| Species | Human |
| Gene Type | protein-coding |
| Description | glycoprotein (transmembrane) nmb |
| Other Description | glycoprotein NMB|glycoprotein nmb-like protein|osteoactivin|transmembrane glycoprotein HGFIN|transmembrane glycoprotein NMB |
| Swissprots | A4D155 Q6UVX1 Q8N1A1 Q14956 |
| Accessions | AAN59897 AAP22336 AAP22337 EAL24259 EAW93781 EAW93782 EAW93783 EAW93784 Q14956 AF322909 AAG42839 AI952217 AJ505015 CAD43718 AK292078 BAF84767 AK296779 BAG59357 AK297031 BAG59559 AK297051 BAG59577 AK297055 BAG59580 AK297803 BAG60141 AK303071 BAG64187 AK304671 BAG65446 AK312279 BAG35208 AY359124 AAQ89481 BC011595 AAH11595 BC025297 BC032783 AAH32783 BM750843 BT007074 AAP35737 BU537639 CD105306 DQ892084 ABM83010 DQ895277 ABM86203 X76534 CAA54044 XM_005249578 XP_005249635 NM_001005340 NP_001005340 NM_002510 NP_002501 |
| Function | Could be a melanogenic enzyme. {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Detected at the cell surface in different types of cancers cells, including glioblastoma multiforme cells and most melanoma cell lines. |
| Tissue Specificity | Up-regulated in various cancer cells, including in glioblastoma multiforme. Expressed in many melanoma cells, as well as in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level). Hardly detectable in healthy brain. {ECO:0000269|PubMed:16489096, ECO:0000269|PubMed:16609006, ECO:0000269|PubMed:7814155}. |
GPNMB CRISPR/Cas9 KO Plasmid (h) - sc-402966 from Santa Cruz Biotechnology
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GPNMB HDR Plasmid (h) - sc-402966-HDR from Santa Cruz Biotechnology
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GPNMB Double Nickase Plasmid (h) - sc-402966-NIC from Santa Cruz Biotechnology
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GPNMB Double Nickase Plasmid (h2) - sc-402966-NIC-2 from Santa Cruz Biotechnology
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GPNMB CRISPR Activation Plasmid (h) - sc-402966-ACT from Santa Cruz Biotechnology
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GPNMB CRISPR Activation Plasmid (h2) - sc-402966-ACT-2 from Santa Cruz Biotechnology
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GPNMB Lentiviral Activation Particles (h) - sc-402966-LAC from Santa Cruz Biotechnology
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GPNMB Lentiviral Activation Particles (h2) - sc-402966-LAC-2 from Santa Cruz Biotechnology
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GPNMB siRNA (h) - sc-60721 from Santa Cruz Biotechnology
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GPNMB shRNA Plasmid (h) - sc-60721-SH from Santa Cruz Biotechnology
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GPNMB shRNA (h) Lentiviral Particles - sc-60721-V from Santa Cruz Biotechnology
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Osteoactivin/GPNMB RNAi - H00010457-R02 from Novus Biologicals
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Osteoactivin/GPNMB RNAi - H00010457-R01 from Novus Biologicals
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MISSION® esiRNA - EHU017981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9537 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9537 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06878 from Sigma-Aldrich
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GPNMB siRNA (Human) - CRH7095 from Cohesion Biosciences
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GPNMB - MBS826971 from MyBioSource
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shRNA set against Human GPNMB (NM_002510.2) - SHH306006 from Creative biogene
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shRNA set against Human GPNMB(NM_002510.2) - SHH096779 from Creative biogene
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shRNA set against Human GPNMB(NM_001005340.1) - SHH096785 from Creative biogene
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shRNA set against Human GPNMB(NM_002510.2) - SHH096821 from Creative biogene
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GPNMB shRNA Plasmid (Human) - CHH7095 from Cohesion Biosciences
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GPNMB miRNA 3'UTR clone - MiUTR1H-04169 from Creative biogene
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