| Gene Symbol | ALKBH8 |
|---|---|
| Entrez Gene | 91801 |
| Alt Symbol | ABH8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | alkB, alkylation repair homolog 8 (E. coli) |
| Other Description | AlkB homologue 8|S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8|alkylated DNA repair protein alkB homolog 8|probable alpha-ketoglutarate-dependent dioxygenase ABH8|tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8 |
| Swissprots | Q96BT7 Q8N989 B4DEF6 B1Q2M0 |
| Accessions | EAW67088 EAW67089 EAW67090 Q96BT7 AB218768 BAG16270 AF086489 AK095523 BAC04566 AK293603 BAG57067 AK298800 BAG60935 AK304413 BAG65244 BC015183 AAH15183 BX649085 HQ447168 ADQ31655 XM_005271728 XP_005271785 XM_005271729 XP_005271786 XM_005271730 XP_005271787 XM_005271732 XP_005271789 XM_011543067 XP_011541369 NM_001301010 NP_001287939 NM_138775 NP_620130 |
| Function | Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:20308323}. Nucleus {ECO:0000269|PubMed:20308323}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:20308323}. |
| Tissue Specificity | Widely expressed, with highest expression in spleen, followed by pancreas and lung. {ECO:0000269|PubMed:17979886}. |
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), Human, ELISA Kit - E01A1396 from ARP American Research Products
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7203843 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7206926 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7212053 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7218477 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7235893 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7243325 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7234367 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7240029 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7240290 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7209586 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7212944 from MyBioSource
|
||||||
Alkylated DNA repair protein alkB homolog 8 (ALKBH8), ELISA Kit - MBS7241445 from MyBioSource
|
||||||
Human ALKBH8 ELISA Kit - E001405 from Biobool
|
||||||
Alkylated DNA repair protein alkB homolog 8, ELISA Kit - MBS283883 from MyBioSource
|