ALKBH8

Gene Symbol	ALKBH8
Entrez Gene	91801
Alt Symbol	ABH8
Species	Human
Gene Type	protein-coding
Description	alkB, alkylation repair homolog 8 (E. coli)
Other Description	AlkB homologue 8|S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8|alkylated DNA repair protein alkB homolog 8|probable alpha-ketoglutarate-dependent dioxygenase ABH8|tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
Swissprots	Q96BT7 Q8N989 B4DEF6 B1Q2M0
Accessions	EAW67088 EAW67089 EAW67090 Q96BT7 AB218768 BAG16270 AF086489 AK095523 BAC04566 AK293603 BAG57067 AK298800 BAG60935 AK304413 BAG65244 BC015183 AAH15183 BX649085 HQ447168 ADQ31655 XM_005271728 XP_005271785 XM_005271729 XP_005271786 XM_005271730 XP_005271787 XM_005271732 XP_005271789 XM_011543067 XP_011541369 NM_001301010 NP_001287939 NM_138775 NP_620130
Function	Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:20308323}. Nucleus {ECO:0000269|PubMed:20308323}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:20308323}.
Tissue Specificity	Widely expressed, with highest expression in spleen, followed by pancreas and lung. {ECO:0000269|PubMed:17979886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALKBH8 full length protein - ab127259 from Abcam Category Protein Prices $364.00 Sizes 50 µg Source E. coli Species Human

ALKBH8 Antibody Blocking Peptide - LS-E8474 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALKBH8 Antibody Blocking Peptide - LS-E15092 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ALKBH8 Antibody Blocking Peptide - LS-E15093 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ALKBH8 Protein - H00091801-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

ALKBH8-Antibody-C-term-Blocking-Peptide - BP6801b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALKBH8 Blocking Peptide - 33R-5870 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALKBH8 Blocking Peptide - 33R-2365 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ALKBH8 - H00091801-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Recombinant Human Alkylated DNA repair protein alkB homolog 8(ALKBH8) - CSB-YP842644HU CSB-EP842644HU CSB-BP842644HU CSB-MP842644HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Alkylated DNA repair protein alkB homolog 8 (ALKBH8) - MBS1324589 from MyBioSource Category Protein Prices $2,495.00, $2,495.00, $2,915.00, $2,915.00 Sizes 1 mg (E Coli Derived), 100 µg (Baculovirus Derived), 1 mg (Yeast Derived), 100 µg (Mammalian Cell Derived) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

ALKBH8 - TP329328 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ALKBH8 Protein - NBP2-38428PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ALKBH8 Protein - NBP2-38928PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

ALKBH8 Recombinant Protein Antigen - NBP1-81238PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ALKBH8 Peptide, Human - M34GP00518H from Creative Peptides Category Peptide Source Synthetic. Species Human

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