ALKBH8

Gene Symbol	ALKBH8
Entrez Gene	91801
Alt Symbol	ABH8
Species	Human
Gene Type	protein-coding
Description	alkB, alkylation repair homolog 8 (E. coli)
Other Description	AlkB homologue 8|S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8|alkylated DNA repair protein alkB homolog 8|probable alpha-ketoglutarate-dependent dioxygenase ABH8|tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
Swissprots	Q96BT7 Q8N989 B4DEF6 B1Q2M0
Accessions	EAW67088 EAW67089 EAW67090 Q96BT7 AB218768 BAG16270 AF086489 AK095523 BAC04566 AK293603 BAG57067 AK298800 BAG60935 AK304413 BAG65244 BC015183 AAH15183 BX649085 HQ447168 ADQ31655 XM_005271728 XP_005271785 XM_005271729 XP_005271786 XM_005271730 XP_005271787 XM_005271732 XP_005271789 XM_011543067 XP_011541369 NM_001301010 NP_001287939 NM_138775 NP_620130
Function	Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269|PubMed:19293182, ECO:0000269|PubMed:20123966, ECO:0000269|PubMed
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17979886, ECO:0000269|PubMed:20308323}. Nucleus {ECO:0000269|PubMed:20308323}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:20308323}.
Tissue Specificity	Widely expressed, with highest expression in spleen, followed by pancreas and lung. {ECO:0000269|PubMed:17979886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ALKBH8 Gene cDNA Clone - orb141778 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-ALKBH8-cDNA-Clone - DC04037 from Abgent, a WuXi AppTec company Prices $321.30 Sizes 10 µg Species Human Accession BC015183

ALKBH8 - MBS1278221 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015183

Human ALKBH8 cDNA clone(NM_138775.2) - CDFG008261 from Creative Biomart Species Human Accession NM_138775.2

Human ALKBH8 ORF Clone(NM_138775.2) - CDCL153658 from Creative Biomart Species Human Accession NM_138775.2

Human ALKBH8 ORF Clone(NM_138775.2) - CDCR316888 from Creative Biomart Species Human Accession NM_138775.2

Human ALKBH8 ORF Clone(NM_138775.2) - CDCR316890 from Creative Biomart Species Human Accession NM_138775.2

Human ALKBH8/ABH8 Gene ORF cDNA clone in cloning vector - HG14208-G from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid - HG14208-UT from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14208-CY from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14208-NF from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14208-NM from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14208-CF from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14208-CM from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, N-His tag - HG14208-NH from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG14208-ACG from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14208-ANG from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, C-His tag - HG14208-CH from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14208-NY from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14208-ACR from Sino Biological Species Human

Human ALKBH8/ABH8 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14208-ANR from Sino Biological Species Human

Human ALKBH8 ORF clone (NM_138775.2) - CDCR026872 from Creative biogene Species Human

Human ALKBH8 ORF Clone (BC015183) - CDCS416808 from Creative biogene Species Human Accession Q96BT7

Human ALKBH8 ORF clone (BC015183) - CDCB159295 from Creative biogene Species Human

Human ALKBH8 cDNA Clone(NM_138775.2) - CDFG008261 from Creative biogene Species Human

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