GRK6

Gene Symbol	GRK6
Entrez Gene	2870
Alt Symbol	GPRK6
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 6
Other Description	-
Swissprots	O60541 P43250 Q13652
Accessions	AAA03565 AAC09262 EAW84997 EAW84998 EAW84999 EAW85000 EAW85001 P43250 AF040751 AAC09273 AF040752 AAC09274 AK056697 BAG51787 BC009277 AAH09277 BC017272 AAH17272 BE965975 BI258860 BU507609 BX382886 JF432223 ADZ15440 L16862 AAA60175 XM_006714858 XP_006714921 XM_006714859 XP_006714922 XM_011534537 XP_011532839 XM_011534538 XP_011532840 NM_001004105 NP_001004105 NM_001004106 NP_001004106 NM_002082 NP_002073
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
Subcellular Location	Membrane; Lipid-anchor.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8415712}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

G protein-coupled receptor kinase 6 (GRK6), Human, ELISA Kit - CSB-EL009927HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 31.25 pg/ml Range 125 pg/ml-8000 pg/ml

GRK6 (Human) IP-WB Antibody Pair - H00002870-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

G protein-coupled receptor kinase 6, ELISA Kit - MBS916331 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 31.25 pg/ml. Range 125 pg/ml -8000 pg/ml.

Human G protein-coupled receptor kinase 6(GRK6) ELISA kit - CSB-EL009927HU from Cusabio Category ELISA Kit Sensitivity 31.25 pg/ml. Range 125 pg/ml-8000 pg/ml

Human GRK6 ELISA Kit - E015850 from Biobool Category ELISA Kit Sensitivity 31.25 pg/ml.

GRK6 ELISA Kit (Human) (OKCA00680) - OKCA00680 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 31.25 pg/mL Range 125 pg/mL-8,000 pg/mL

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