| Gene Symbol |
GRK6
|
| Entrez Gene |
2870
|
| Alt Symbol |
GPRK6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor kinase 6
|
| Other Description |
-
|
| Swissprots |
O60541 P43250 Q13652
|
| Accessions |
AAA03565 AAC09262 EAW84997 EAW84998 EAW84999 EAW85000 EAW85001 P43250 AF040751 AAC09273 AF040752 AAC09274 AK056697 BAG51787 BC009277 AAH09277 BC017272 AAH17272 BE965975 BI258860 BU507609 BX382886 JF432223 ADZ15440 L16862 AAA60175 XM_006714858 XP_006714921 XM_006714859 XP_006714922 XM_011534537 XP_011532839 XM_011534538 XP_011532840 NM_001004105 NP_001004105 NM_001004106 NP_001004106 NM_002082 NP_002073
|
| Function |
Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
|
| Subcellular Location |
Membrane; Lipid-anchor.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8415712}.
|
| Top Pathways |
Endocytosis, Chemokine signaling pathway, Morphine addiction
|