GRK6

Gene Symbol	GRK6
Entrez Gene	2870
Alt Symbol	GPRK6
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 6
Other Description	-
Swissprots	O60541 P43250 Q13652
Accessions	AAA03565 AAC09262 EAW84997 EAW84998 EAW84999 EAW85000 EAW85001 P43250 AF040751 AAC09273 AF040752 AAC09274 AK056697 BAG51787 BC009277 AAH09277 BC017272 AAH17272 BE965975 BI258860 BU507609 BX382886 JF432223 ADZ15440 L16862 AAA60175 XM_006714858 XP_006714921 XM_006714859 XP_006714922 XM_011534537 XP_011532839 XM_011534538 XP_011532840 NM_001004105 NP_001004105 NM_001004106 NP_001004106 NM_002082 NP_002073
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
Subcellular Location	Membrane; Lipid-anchor.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8415712}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GRK6 full length protein - ab125576 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human GRK6 full length protein - ab158572 from Abcam Category Protein Source Wheat germ Species Human

Human GRK6 protein fragment - ab158571 from Abcam Category Protein Source Wheat germ Species Human

Human GRK6 protein fragment - ab158573 from Abcam Category Protein Source Wheat germ Species Human

GRK6 Antibody Blocking Peptide - LS-E22470 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRK6 Antibody Blocking Peptide - LS-E8600 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GRK6 Protein - H00002870-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human GRK6 Protein - H00002870-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GRK6 Peptide - P2091 from Novus Biologicals Category Peptide Species Human

GRK6-Antibody-C-term-Blocking-Peptide - BP7008a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human GRK 6 protein - orb84148 from Biorbyt Category Protein Prices $323.00, $400.00 Sizes 20 μg, 10 μg Source Insect Species Human

GRK6 Blocking Peptide - abx062691 from Abbexa Category Peptide Species Human, Mouse, Rat

GRK6 - H00002870-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

GRK6 - H00002870-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GRK6 - H00002870-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GRK6 - P5556 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

GRK6 Peptide - 7641P from ProSci Category Peptide Species Human

GRK6 fusion protein - Ag1992 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human GRK6, His & GST tagged - GRK6-974H from Creative Biomart Category Protein Source Baculovirus-Insect Cells Species Human

Recombinant Human GRK6, GST-tagged - GRK6-13542H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human G Protein-Coupled Receptor Kinase 6, GST-tagged - GRK6-1020H from Creative Biomart Category Protein Species Human

Recombinant Human G Protein-Coupled Receptor Kinase 6, GST-tagged - GRK6-1233H from Creative Biomart Category Protein Source Insect cells Species Human

GRK6 / GPRK6 - PN201660 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Baculovirus Species Human

Recombinant G Protein Coupled Receptor Kinase 6 (GRK6) - RPC194Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Human GRK6 / GPRK6 Protein (His & GST Tag) - 11752-H20B-10 from Sino Biological Category Protein Source Baculovirus-Insect Cells Species Human

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