GRK6

Gene Symbol	GRK6
Entrez Gene	2870
Alt Symbol	GPRK6
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 6
Other Description	-
Swissprots	O60541 P43250 Q13652
Accessions	AAA03565 AAC09262 EAW84997 EAW84998 EAW84999 EAW85000 EAW85001 P43250 AF040751 AAC09273 AF040752 AAC09274 AK056697 BAG51787 BC009277 AAH09277 BC017272 AAH17272 BE965975 BI258860 BU507609 BX382886 JF432223 ADZ15440 L16862 AAA60175 XM_006714858 XP_006714921 XM_006714859 XP_006714922 XM_011534537 XP_011532839 XM_011534538 XP_011532840 NM_001004105 NP_001004105 NM_001004106 NP_001004106 NM_002082 NP_002073
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
Subcellular Location	Membrane; Lipid-anchor.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8415712}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRK6-Over-expression-Lysate - LY11610a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

GRK6 293T Cell Transient Overexpression Lysate(Denatured) - H00002870-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

GRK6 overexpression lysate - LY419550 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

GRK6 293 Cell Lysate - 409149 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

GRK6 Overexpression Lysate (Native) - NBL1-11344 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

GRK6 Overexpression Lysate (Native) - NBP2-08929 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

GRK 6 (h): 293T Lysate - sc-158578 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

GRK6 Over-expression Lysate Product - GWB-1DBBBC from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human GRK6 / GPRK6 Insect Cell Lysate (WB positive control) - 11752-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human GRK6 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175008 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

GRK6 Overexpression Lysate (Denatured) - H00002870-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

GRK6-knockout Cell lysate - LC810094 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human GRK6 Knockdown Stable Cell Line - CSC-DC006672 from Creative biogene Category Cell Line Species Human

Human GRK6 Knockout Cell Line-HeLa - CSC-RT0839 from Creative biogene Category Cell Line Species Human

GRK6 KO Cell Lysate-HeLa - CLKO-0342 from Creative biogene Category Cell Lysate

Search more