GRK6

Gene Symbol	GRK6
Entrez Gene	2870
Alt Symbol	GPRK6
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 6
Other Description	-
Swissprots	O60541 P43250 Q13652
Accessions	AAA03565 AAC09262 EAW84997 EAW84998 EAW84999 EAW85000 EAW85001 P43250 AF040751 AAC09273 AF040752 AAC09274 AK056697 BAG51787 BC009277 AAH09277 BC017272 AAH17272 BE965975 BI258860 BU507609 BX382886 JF432223 ADZ15440 L16862 AAA60175 XM_006714858 XP_006714921 XM_006714859 XP_006714922 XM_011534537 XP_011532839 XM_011534538 XP_011532840 NM_001004105 NP_001004105 NM_001004106 NP_001004106 NM_002082 NP_002073
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
Subcellular Location	Membrane; Lipid-anchor.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8415712}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRK6 (D1A4) Rabbit mAb - 5878 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D1A4

GRK 6 (C-20) - sc-566 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GRK 6 (D-10) - sc-377494 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

GRK 6 (H-70) - sc-13080 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GRK 6 (XX-4) - sc-100380 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

Anti-GRK6 antibody - ab106673 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GRK6 antibody - ab64915 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GRK6 antibody - ab137814 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 antibody - ab137713 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 antibody - ab55143 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-GRK6 antibody - ab172016 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-GRK6 antibody [EPR2046(2)] - ab109302 from Abcam Prices $313.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2046(2)

Anti-GRK6 antibody - Carboxyterminal end - ab38291 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus, AP) - LS-C219655 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus, APC) - LS-C219657 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus, Biotin) - LS-C219658 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus, FITC) - LS-C219659 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (aa375-424) - LS-C151450 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus, PE) - LS-C219661 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus, Azide-free, HRP) - LS-C219660 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (Internal, clone EPR2046(2)) - LS-C138249 from LifeSpan Bioscience Prices $395.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2046(2)

Anti-GRK6 Antibody - LS-C310520 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody - LS-C308120 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-GRK6 Antibody (C-Terminus) - LS-C327489 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-GRK6 Antibody (aa10-59) - LS-C118894 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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