GRK6

Gene Symbol	GRK6
Entrez Gene	2870
Alt Symbol	GPRK6
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 6
Other Description	-
Swissprots	O60541 P43250 Q13652
Accessions	AAA03565 AAC09262 EAW84997 EAW84998 EAW84999 EAW85000 EAW85001 P43250 AF040751 AAC09273 AF040752 AAC09274 AK056697 BAG51787 BC009277 AAH09277 BC017272 AAH17272 BE965975 BI258860 BU507609 BX382886 JF432223 ADZ15440 L16862 AAA60175 XM_006714858 XP_006714921 XM_006714859 XP_006714922 XM_011534537 XP_011532839 XM_011534538 XP_011532840 NM_001004105 NP_001004105 NM_001004106 NP_001004106 NM_002082 NP_002073
Function	Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro). {ECO:0000250, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
Subcellular Location	Membrane; Lipid-anchor.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:8415712}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRK 6 CRISPR/Cas9 KO Plasmid (h) - sc-402061 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 HDR Plasmid (h) - sc-402061-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 Double Nickase Plasmid (h) - sc-402061-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 Double Nickase Plasmid (h2) - sc-402061-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 CRISPR Activation Plasmid (h) - sc-402061-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 CRISPR Activation Plasmid (h2) - sc-402061-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 Lentiviral Activation Particles (h) - sc-402061-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 Lentiviral Activation Particles (h2) - sc-402061-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

GRK 6 siRNA (h) - sc-35518 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRK 6 shRNA Plasmid (h) - sc-35518-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRK 6 shRNA (h) Lentiviral Particles - sc-35518-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

GRK6 RNAi - H00002870-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

GRK6 RNAi - H00002870-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

GRK6 RNAi - H00002870-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU115571 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0860 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0861 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0862 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1350 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1350 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR07778 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr07778

GRK6 siRNA (Human) - CRH1928 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

GRK6 - MBS8225889 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human GRK6 (NM_002082.3) - SHH308066 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human GRK6(NM_001004105.2) - SHH105405 from Creative biogene Category siRNA Species Reactivities Human

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